【Molecular Wt.】127 kDa

【Description】Damaged DNA binding protein (DDB) is a heterodimer composed of two subunits, p127 and p48, which are designated DDB1 and DDB2, respectively. The DDB heterodimer is involved in repairing DNA damaged by ultraviolet light. Specifically, DDB, also designated UV-damaged DNA binding protein (UV-DDB), xeroderma pigmentosum group E binding factor (XPE-BF) and hepatitis B virus X-associated protein 1 (XAP-1), binds to damaged cyclobutane pyrimidine dimers (CPDs). Mutations in the DDB2 gene are implicated as causes of xeroderma pigmentosum group E, an autosomal recessive disease in which patients are defective in nucleotide excision DNA repair. XPE is characterized by hypersensitivity of the skin to sunlight with a high frequency of skin cancer as well as neurologic abnormalities. The hepatitis B virus (HBV) X protein interacts with DDB1, which may mediate HBx transactivation.

【Species Reactivity】Human;Mouse;Rat

【Tested applications】WB;ICC/IF;IHC;IP

【Antibody type】Recombinant Rabbit monoclonal Antibody

【Immunogen】Recombinant protein

【Positive control】HepG2, NIH-3T3, MCF-7, rat kidney tissue lysate, Hela, HUVEC, SH-SY5Y, rat esophagus tissue, human liver cancer tissue, human kidney tissue, mouse brain tissue.

【Conjugate】Non-conjugated

【Alternative names】Damage specific DNA binding protein 1 antibody
Damage-specific DNA-binding protein 1 antibody
DDB 1 antibody
DDB p127 subunit antibody
Ddb1 antibody
DDB1_HUMAN antibody
DDBa antibody
DNA damage binding protein 1 antibody
DNA damage-binding protein 1 antibody
DNA damage-binding protein a antibody
HBV X-associated protein 1 antibody
UV damaged DNA binding factor antibody
UV damaged DNA binding protein 1 antibody
UV DDB 1 antibody
UV DDB1 antibody
UV-damaged DNA-binding factor antibody
UV-damaged DNA-binding protein 1 antibody
UV-DDB 1 antibody
X associated protein 1 antibody
XAP 1 antibody
XAP-1 antibody
XAP1 antibody
Xeroderma pigmentosum group E complementing protein antibody
Xeroderma pigmentosum group E-complementing protein antibody
XPCe antibody
XPE antibody
XPE BF antibody
XPE binding factor antibody
XPE-BF antibody
XPE-binding factor antibody

【Form】Liquid

【Stroage】Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.

【Stroage Buffer】1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

【Isotype】IgG

【Purity】Protein A purified.

【Subcellular location】Cytoplasm, Nucleus.

【Background References】1. Yu C et al. CRL4-DCAF1 ubiquitin E3 ligase directs protein phosphatase 2A degradation to control oocyte meiotic maturation. Nat Commun 6:8017 (2015).
2. Tamayo AG et al. Histone monoubiquitination by Clock-Bmal1 complex marks Per1 and Per2 genes for circadian feedback. Nat Struct Mol Biol 22:759-66 (2015).

【DatasheetURL】http://www.huabio.com/upload/ET1706-22.pdf

【Uniprot ID】Q16531(Human) Q3U1J4(Mouse) Q9ESW0(Rat)

【Raised in】Rabbit

【Clone No.】JU32-35