产品货号 : jlcR6968 英文名称 : HLA DM 中文名称 : 组织相容性复合体α抗体 别名 : Class II histocompatibility antigen M alpha chain; D6S222E; DMA; HLA class II histocompatibility antigen DM alpha chain; HLA DMA; HLADM; Major histocompatibility complex class II DM alpha; MHC class II antigen DMA; Really interesting new gene 6 protein; Ring 6; Ring6; DMA_HUMAN. 研究领域 : 细胞生物免疫学 抗体来源 : Rabbit 克隆类型 : Polyclonal 交叉反应 : Human, Mouse, Rat, Dog, Pig, Cow, Horse, 产品应用 : WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. 分子量 : 26kDa 细胞定位 : 细胞浆细胞膜 性状 : Lyophilized or Liquid 浓度 : 1mg/ml 免疫原 : KLH conjugated synthetic peptide derived from human HLA DM:101-200/261 亚型 : IgG 纯化方法 : affinity purified by Protein A 储存液 : 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 保存条件 : Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. PubMed : PubMed 产品介绍 : Human Leukocyte Antigens are highly polymorphic proteins that are involved in the presentation of antigens to the T-cell receptor. There are two classes of HLA antigens, class I (HLA-A, HLA-B and HLA-C) and class II (HLA-D). This antibody can be used for HLA typing. HLA DM plays a critical role in catalyzing the release of class II HLA-associated invariant chain-derived peptides (CLIP) from newly synthesized class II HLA molecules and freeing the peptide binding site for acquisition of antigenic peptides.
Subunit: Heterodimer of an alpha chain (DMA) and a beta chain (DMB).
Subcellular Location: Late endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein.
Similarity: Belongs to the MHC class II family. Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
SWISS: P28067
Gene ID: 3108
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
