产品货号:jlcR9713
英文名称:FAD24/NOC3L
中文名称:脂肪细胞分化因子24抗体
别名:C10orf117; FAD24; AD24; Factor for adipocyte differentiation 24; NOC3 like protein; NOC3 protein homolog; NOC3-like protein; noc3l; NOC3L_HUMAN; Nucleolar complex associated 3 homolog (S. cerevisiae); Nucleolar complex associated protein 3 like protein; Nucleolar complex protein 3 homolog; Nucleolar complex-associated protein 3-like protein.
研究领域:细胞生物免疫学信号转导细胞周期蛋白细胞分化表观遗传学
抗体来源:vRabbit
克隆类型:Polyclonal
交叉反应:Human, Mouse, Dog, Cow, Horse, Rabbit, Sheep,
产品应用:ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分子量:93kDa
细胞定位:细胞核
性状:Lyophilized or Liquid
浓度:1mg/ml
免疫原:KLH conjugated synthetic peptide derived from human NOC3L/FAD24:1-100/800
亚型:IgG
纯化方法:affinity purified by Protein A
储存液:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件:Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed:PubMed
产品介绍background:
GADD 153, a growth arrest and DNA damage-inducible gene, encodes a C/EBP-related nuclear protein. This protein has also been designated C/EBP-homologous protein (CHOP-10 or C/EBP zeta). GADD 153 expression is induced by a variety of cellular stresses, inducing nutrient deprivation and metabolic perturbations. GADD 153 functions to block cells in G1 to S phase during cell cycle progression and acts by dimerizing with other C/EBP proteins to direct GADD 153 dimers away from “classical” C/EBP binding sites, recognizing instead unique “nonclassical” sites. Thus, GADD 153 acts as a negative modulator of C/EBP-like proteins in certain terminally differentiated cells. GADD 153 belongs to the CBF/MAK21 family, which also includes NOC2L, NOC3L and NOC4L. NOC3L, also designated factor for adipocyte differentiation 24 or Fad24, promotes adipogenesis by controlling DNA replication during the early stages of mitotic clonal expansion (MCE).
Function:
May be required for adipogenesis.
Subcellular Location:
Nucleus
Tissue Specificity:
Expressed in colon, heart, kidney, liver, lung, placenta, skeletal muscle, small intestine, spleen and thymus.
Similarity:
Belongs to the CBF/MAK21 family.
SWISS:
Q8WTT2
Gene ID:
64318
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
