本公司提供科研PAK4小鼠抗p21激活激酶4抗体，抗体质量可靠，订购PAK4小鼠抗p21激活激酶4抗体请联系在线客服或者销售人员。
抗体参数如下>>>>
中文名称：小鼠抗p21激活激酶4抗体
英文名称：Anti-PAK4
货号：bs-3517M
抗体来源：鼠
克隆类型：多克隆
蛋白分子量：predicted molecular weight: 64kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, cow, Rb, dog, chk
测试应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
产品背景介绍：p21-activated kinases (PAKs) belong to the family of serine/threonine kinases involved in the control of various cellular processes, including the cell cycle, dynamics of the cytoskeleton, apoptosis, oncogenic transformation, and transcription. All PAK family members are characterized by the presence of p21-binding domain. p21-activated kinases are regulated by the small GTP-binding proteins Rac and Cdc42, and lipids, which stimulate autophosphorylation and phosphorylation of exogenous substrates. Serine (Ser-474) is the likely autophosphorylation site in the kinase domain of PAK4 in vivo. Phosphospecific antibodies directed against serine 474 detect activated PAK4 on the Golgi membrane when PAK4 is co-expressed with activated Cdc42. Current data strongly implicates PAK-4 in oncogenesis. PAK4 is frequently overexpressed in human tumor cell lines of various tissue origins.丝氨酸/苏氨酸蛋白激酶4 (PAK4)是新发现的一类蛋白因子，在细胞信号转导过程中起很重要的作用， Pak4常在人体的多种组织器官的肿瘤细胞中呈现过表达，他的丝氨酸位点很可能是Pak4酶活性区域中的自身磷酸化位点，丝氨酸到谷氨酸位点的突变体促使其获得了酶活性。在肿瘤遗传学、细胞癌变、细胞凋亡等一些重要的细胞生物学研究中，具有重要的意义。