本公司提供科研SCN11A/NAV1.9钠通道蛋白11α抗体，抗体质量可靠，订购SCN11A/NAV1.9钠通道蛋白11α抗体请联系在线客服或者销售人员。
抗体参数如下>>>>
中文名称：钠通道蛋白11α抗体
英文名称：Anti-SCN11A/NAV1.9
货号：bs-6684R
抗体来源：兔
克隆类型：多克隆
蛋白分子量：predicted molecular weight: 197kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, cow, pig, dog, hrs, chk, Rb
测试应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
产品背景介绍：Voltage gated sodium channels are membrane protein complexes that play a fundamental role in generating and transmitting action potentials in neuronal cells. SCN11A (Sodium channel, voltage gated, type XI, alpha subunit) mediates the voltage dependent sodium ion permeability and conductance. It forms the pore of the sodium selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin resistant sodium channel isoform.Function : This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant sodium channel isoform. Also involved, with the contribution of the receptor tyrosine kinase NTRK2, in rapid BDNF-evoked neuronal depolarization.Subunit : he voltage-resistant sodium channel consists of an ion conducting pore forming alpha-subunit regulated by one or more auxiliary subunits SCN1B, SCN2B and SCN3B.Subcellular Location : Membrane; Multi-pass membrane protein.Tissue Specificity : Expressed in the dorsal root ganglia and trigeminal ganglia, olfactory bulb, hippocampus, cerebellar cortex, spinal cord, spleen, small intestine and placenta.Similarity : Belongs to the sodium channel (TC 1.A.1.10) family. Nav1.9/SCN11A subfamily.