本公司提供科研Nebulette肌动蛋白结合蛋白Z盘状蛋白抗体，抗体质量可靠，订购Nebulette肌动蛋白结合蛋白Z盘状蛋白抗体请联系在线客服或者销售人员。
抗体参数如下>>>>
中文名称：肌动蛋白结合蛋白Z盘状蛋白抗体
英文名称：Anti-Nebulette
货号：bs-9468R
抗体来源：兔
克隆类型：多克隆
蛋白分子量：predicted molecular weight: 30kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, dog
测试应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
产品背景介绍：Nebulette binds to actin and plays an important role in Z-disk assembly. It is a cardiac homolog of nebulin and its expression is abundant in cardiac muscle. Nebulette defects are assocated with non-familial idiopathic cardiacmyopathy.Nebulin and nebulette are homologous thin-filament associated proteins expressed in skeletal and cardiac muscles, respectively. Nebulette, unlike nebulin, is confined to the Z-disc region of the sarcomere and does not span the whole thin filament length. Nebulette colocalizes with α-actinin in the pre-, nascent, and mature myofibrils. A polymorphism in the actin-binding motif of nebulette is a genetic marker of susceptibility to nonfamilial idiopathic dilated cardiomyopathy (IDC), characterized by a thin-walled heart and systolic dysfunction.Subcellular Location : Cytoplasmic.