本公司提供科研Phospho-WNK1(Thr60)磷酸化赖氨酸缺陷型蛋白激酶1抗体，抗体质量可靠，订购Phospho-WNK1(Thr60)磷酸化赖氨酸缺陷型蛋白激酶1抗体请联系在线客服或者销售人员。
抗体参数如下>>>>
中文名称：磷酸化赖氨酸缺陷型蛋白激酶1抗体
英文名称：Anti-Phospho-WNK1(Thr60)
货号：bs-3473R
抗体来源：兔
克隆类型：多克隆
蛋白分子量：predicted molecular weight: 262kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, cow, dog, pig, chk, Rb
测试应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
产品背景介绍：WNK1 controls sodium and chloride ion transport by inhibiting the activity of WNK4, potentially by either phosphorylating the kinase or via an interaction between WNK4 and the autoinhibitory domain of WNK1. WNK4 regulates the activity of the thiazide sensitive Na/Cl cotransporter, SLC12A3, by phosphorylation. WNK1 may also play a role in actin cytoskeletal reorganization.WNK1 has 4 isoforms produced by alternative splicing. WNK1 is widely expressed, with highest levels observed in the testis, heart, kidney and skeletal muscle.Defects in WNK1 are a cause of pseudohypoaldosteronism type II (PHAII), an autosomal dominant disease characterized by severe hypertension, hyperkalemia, and sensitivity to thiazide diuretics which may result from a chloride shunt in the renal distal nephron.Subunit : Interacts with SYT2. Interacts with WNK3 and WNK4.Subcellular Location : Cytoplasm.Tissue Specificity : Widely expressed, with highest levels observed in the testis, heart, kidney and skeletal muscle. Isoform 3 is kidney-specific.Similarity : Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WNK subfamily.Contains 1 protein kinase domain.