关键词：Topo IIIβ-1抗体;DNA拓扑异构酶IIIβ-1抗体;DNA拓扑异构酶IIIβ-1;TOP3B; TOP3B1; DNA topoisomerase 3-beta-1; DNA topoisomerase III beta-1

中文名称：DNA拓扑异构酶IIIβ-1多克隆抗体/Topo IIIβ-1 Polyclonal Antibody

英文名称：Topo IIIβ-1 Polyclonal Antibody

产品说明书：http://www.abbkine.cn/datasheet/ABP52628.pdf

产品描述：兔抗-DNA拓扑异构酶IIIβ-1 多克隆抗体

TOP3B encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus relaxing the supercoils and altering the topology of DNA. The enzyme interacts with DNA helicase SGS1 and plays a role in DNA recombination, cellular aging and maintenance of genome stability. Low expression of this gene may be related to higher survival rates in breast cancer patients. This gene has a pseudogene on chromosome 22. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known.

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