【Molecular Wt.】80 kDa

【Description】The transcription factor NFκB is retained in the cytoplasm in an inactive form by the inhibitory protein IκB. Activation of NFκB requires that IκB be phosphorylated on specific serine residues, which results in targeted degradation of IκB. IκB kinase α (IKKα), previously designated CHUK, interacts with IκB-α and specifically phosphorylates IκB-α on the sites that trigger its degradation, Serines 32 and 36. The functional IKK complex contains three subunits, IKKα, IKKβ and IKKγ (also designated NEMO), and each appear to make essential contributions to IκB phosphorylation. TANK binding kinase (TBK1), also designated T2K, is a novel IKK-related kinase that has been identified in murine and human tissues. TBK1 was shown to complex with TRAF2 and TANK in the NFκB activation pathway. TBK1 shares homology with IKKα and IKKβ in the amino-terminal half, which includes the kinase domain.

【Species Reactivity】Human;Mouse;Rat

【Tested applications】WB;IP

【Antibody type】Mouse monoclonal Antibody

【Immunogen】peptide

【Positive control】RAW264.7, MCF7, KNRK.

【Conjugate】Non-conjugated

【Alternative names】EC 2.7.11.1 antibody
FLJ11330 antibody
NAK antibody
NF kappa B activating kinase antibody
NF kB activating kinase antibody
NF-kappa-B-activating kinase antibody
Serine/threonine protein kinase TBK 1 antibody
Serine/threonine protein kinase TBK1 antibody
Serine/threonine-protein kinase TBK1 antibody
T2K antibody
TANK binding kinase 1 antibody
TANK-binding kinase 1 antibody
TBK 1 antibody
Tbk1 antibody
TBK1_HUMAN antibody

【Form】Liquid

【Stroage】Store at +4℃

【Stroage Buffer】1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

【Isotype】IgG1

【Purity】Protein A purified.

【Subcellular location】Cytoplasm

【Background References】1. Chen, H., et al. 2011. Activation of STAT6 by STING is critical for antiviral innate immunity. Cell 147: 436-446.
2. Neerincx, A., et al. 2010. A role for the human NLR family member NLRC5 in antiviral responses. J. Biol. Chem. 285: 26223-26232.

【DatasheetURL】http://www.huabio.com/upload/RT1413.pdf

【Uniprot ID】Q9UHD2

【Raised in】Mouse

【Clone No.】2G1