【Molecular Wt.】90 kDa

【Description】Netrin receptor DCC (deleted colorectal careinoma) was originally identified as a putative tumor suppressor gene that is lost in more than 70% of colorectal cancers. The DCC protein is a type I transmembrane glycoprotein that belongs to the immunoglobulin (Ig) superfamily. It is found in axons of the central and peripheral nervous system and in differentiated cell types of the intestine. Native DCC is found in three isoforms. Two forms, a long and a short isoform, are produced from the same gene but have different initiation sites. The third isoform, produced by alternative splicing, is expressed only in embryonic tissue. Colorectal tumors that lost their capacity to differentiate into mucus producing cells uniformly lack DCC expression. Inactivation of DCC due to allelic deletion or point mutations may cause both lymphatic and hematogenous metastasis of esophageal squamous cell carcinomas.

【Species Reactivity】Human;mouse

【Tested applications】WB;ICC;IHC;FC

【Antibody type】Rabbit polyclonal Antibody

【Immunogen】recombinant protein

【Positive control】Human brain, mouse brain

【Conjugate】Non-conjugated

【Alternative names】Colorectal cancer related chromosome sequence 18 antibody
Colorectal cancer suppressor antibody
CRC 18 antibody
CRC18 antibody
CRCR 1 antibody
CRCR1 antibody
DCC antibody
DCC_HUMAN antibody
Deleted in colorectal cancer protein antibody
Deleted in colorectal carcinoma antibody
Immunoglobulin superfamily DCC subclass member 1 antibody
Netrin receptor DCC antibody
Tumor suppressor protein DCC antibody

【Form】Liquid

【Stroage】Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.

【Stroage Buffer】1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

【Isotype】IgG

【Purity】Immunogen affinity purified

【Subcellular location】Cell membrane

【Background References】1. "The DCC gene product in cellular differentiation and colorectal tumorigenesis."Hedrick L., Cho K.R., Fearon E.R., Wu T.-C., Kinzler K.W., Vogelstein B.Genes Dev. 8:1174-1183(1994).
2. "Identification of a chromosome 18q gene that is altered in colorectal cancers."Fearon E.R., Cho K.R., Nigro J.M., Kern S.E., Simons J.W., Ruppert J.M., Hamilton S.R., Preisinger A.C., Thomas G., Kinzler K.W., Vogelstein B.Science 247:49-56(1990)

【DatasheetURL】http://www.huabio.com/upload/0911-5.pdf

【Uniprot ID】P43146

【Raised in】Rabbit

【Clone No.】