产品货号:jlcR23676 英文名称:Ctip2 中文名称: B淋巴细胞白血病/淋巴瘤11B抗体 别名:B cell lymphoma/leukemia 11B; B-cell CLL/Lymphoma 11B; B-cell lymphoma/leukemia 11B; BC11B_HUMAN; BCL-11B; Bcl11B; COUP-TF interacting protein 2; COUP-TF-interacting protein 2; Ctip 2; hRit1; MS1029; Radiation induced tumor suppressor gene 1; Radiation induced tumor suppressor gene 1 protein; Radiation-induced tumor suppressor gene 1 protein; Rit 1; Rit1. 研究领域:肿瘤细胞生物神经生物学信号转导转录调节因子淋巴细胞 b-淋巴细胞 锌指蛋白 抗体来源:Rabbit 克隆类型:Polyclonal 交叉反应:Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, 产品应用:WB=1:500-2000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. 分子量:95kDa 细胞定位:细胞核 性状:Lyophilized or Liquid 浓度:1mg/ml 免疫原:KLH conjugated synthetic peptide derived from human Ctip2 :221-320/894 亚型:IgG 纯化方法:affinity purified by Protein A 储存液:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 保存条件:Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. PubMed :PubMed 产品介绍: This gene encodes a C2H2-type zinc finger protein and is closely related to BCL11A, a gene whose translocation may be associated with B-cell malignancies. Although the specific function of this gene has not been determined, the encoded protein is known to be a transcriptional repressor, and is regulated by the NURD nucleosome remodeling and histone deacetylase complex. Four alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Aug 2013]
Function: Tumor-suppressor protein involved in T-cell lymphomas. May function on the P53-signaling pathway. May be a key regulator of both differentiation and survival during thymocyte development. Repress transcription through direct, TFCOUP2-independent binding to a GC-rich response element.
Subunit: Interacts with TFCOUP1, SIRT1, ARP1 and EAR2
Subcellular Location: Nucleus.
Tissue Specificity: Highly expressed in brain and in malignant T-cell lines derived from patients with adult T-cell leukemia/lymphoma.
Similarity: Contains 6 C2H2-type zinc fingers.
SWISS: Q9C0K0
Gene ID: 64919
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
