特别提示：包括重组RNA焦磷酸水解酶在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组RNA焦磷酸水解酶
英文名称：Recombinant E.coli RNA pyrophosphohydrolase
产品货号：JN1478
产品规格：10μg|50μg|500μg|1mg

本品由我们的大肠杆菌表达系统制备而成，目的基因编码的Met1-Gly176表达纯化得来。

RNA pyrophosphohydrolase质量控制：＞95%(还原性SDS-PAGE)

RNA pyrophosphohydrolase制剂：液体

RNA pyrophosphohydrolase保存：收到货后请置于-20℃，可保存6个月，避免反复冻融。

关于RNA pyrophosphohydrolase：
Messenger RNA (mRNA) degradation plays a key role in the control of gene expression in all organisms by limiting the number of times that each mRNA molecule can be used as a template for protein synthesis. RNA pyrophosphohydrolase, also called RppH, is a master regulator of 5-dependent mRNA decay. It accelerates the degradation of transcripts by removing pyrophosphate from the 5-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage. RppH preferentially hydrolyzes diadenosine penta-phosphate with ATP as one of the reaction products, and can be able to hydrolyze diadenosine hexa- and tetra-phosphate. However, this protein has no activity on diadenosine tri-phosphate, ADP-ribose, NADH and UDP-glucose. In the meningitis causing strain E.coli K1, it has been shown to play a role in HBMEC (human brain microvascular endothelial cells) invasion in vitro.

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