Prouduct:We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.This product is a high quality SPARC Antibody(C-term) Antibody(Ascites).Functiong:Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.Summary:Secreted protein acidic and rich incysteine/osteonectin/BM40, or SPARC, is a matrix-associated proteinthat elicits changes in cell shape, inhibits cell-cycleprogression, and influences the synthesis of extracellular matrix(ECM) (Bradshaw et al., 2003 [PubMed 12721366]).