【Molecular Wt.】24 kDa

【Description】Glial cell line-derived neurotrophic factor (GDNF) has been identified as a potent neurotrophic factor that enhances survival of midbrain dopaminergic neurons. GDNF is a glycosylated, disulfide-bonded homodimer and is a distantly related member of the TGFβ superfamily of growth regulatory ligands. GDNF contains the seven conserved cysteine residues in the same relative spacing characteristic of all members of the TGFβ superfamily. In embryonic midbrain cultures, GDNF promotes the survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. On the basis of these findings, it has been suggested that GDNF may have utility in the treatment of Parkinson's disease, which is marked by progressive degeneration of midbrain dopaminergic neurons.

【Species Reactivity】Human;Mouse;Rat

【Tested applications】WB;FC

【Antibody type】Recombinant Rabbit monoclonal Antibody

【Immunogen】recombinant protein

【Positive control】HepG2, SH-SY5Y.

【Conjugate】Non-conjugated

【Alternative names】Astrocyte derived trophic factor antibody
Astrocyte derived trophic factor 1 antibody
Astrocyte-derived trophic factor antibody
ATF 1 antibody
ATF 2 antibody
Atf antibody
ATF1 antibody
ATF2 antibody
gdnf antibody
GDNF_HUMAN antibody
Glial cell derived neurotrophic factor antibody
Glial Cell Line Derived Neurotrophic Factor antibody
Glial cell line-derived neurotrophic factor antibody
Glial derived neurotrophic factor antibody
HFB1 GDNF antibody
hGDNF antibody
HSCR3 antibody

【Form】Liquid

【Stroage】Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.

【Stroage Buffer】1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

【Isotype】IgG

【Purity】Protein A purified.

【Subcellular location】Secreted.

【Background References】1. Li G et al. Preventative effects of fermented Chimonobambusa quadrangularis shoot on activated carbon-induced constipation. Exp Ther Med 13:1093-1100 (2017).
2. Xiong Y et al. Precursor N-cadherin mediates glial cell line-derived neurotrophic factor-promoted human malignant glioma. Oncotarget 8:24902-24914 (2017).

【DatasheetURL】http://www.huabio.com/upload/ET1704-46.pdf

【Uniprot ID】P39905(Human) P48540(Mouse) Q07731(Rat)

【Raised in】Rabbit

【Clone No.】JA93-10