本公司提供科研FoxP3叉头蛋白P3抗体，抗体质量可靠，订购FoxP3叉头蛋白P3抗体请联系在线客服或者销售人员。
抗体参数如下>>>>
中文名称：叉头蛋白P3抗体
英文名称：Anti-FoxP3
货号：bs-0269R
抗体来源：兔
克隆类型：多克隆
蛋白分子量：predicted molecular weight: 47kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, rat, mo
测试应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
产品背景介绍：Fox P3, Forkhead box P3 (also disineted AIID, DIETER, IPEX, JM2, PIDX,SCURFIN, XPID zinc finger protein JM2) Probable is transcription factor. Plays a critical role in the control of immune response. Defects in FOXP3 are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) also known as X-linked autoimmunity-immunodeficiency syndrome. IPEX is characterized by neonatal onset insulin-dependent diabetes mellitus, infections, secretory diarrhea, trombocytopenia, anemia and eczema. It is usually lethal in infancy.Function : Probable transcription factor. Plays a critical role in the control of immune response.Subcellular Location : Nucleus.DISEASE : Defects in FOXP3 are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) [MIM:304790]; also known as X-linked autoimmunity-immunodeficiency syndrome. IPEX is characterized by neonatal onset insulin-dependent diabetes mellitus, infections, secretory diarrhea, trombocytopenia, anemia and eczema. It is usually lethal in infancy.Similarity : Contains 1 C2H2-type zinc finger.Contains 1 fork-head DNA-binding domain.叉头蛋白3(FOXP3)是FOX蛋白家族成员之一,主要为T细胞转录蛋白，主要表达于T细胞+CD4+CD25,并调节该类T细胞的发育和功能. FOXP3的表达受转化生长因子-β雌激素和糖皮质激素等调节,通过竞争性抑制活化T细胞核因子的转录活性而发挥作用.自身免疫性糖尿病患者体内CD4+CD25+T细胞减少,诱导FOXP3的表达或过继转移CD4+CD25+T细胞有可能预防自身免疫性糖尿病产品图片Tissue/cell: rat liver tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-FoxP3 Polyclonal Antibody, Unconjugated(bs-0269R) 1:100, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining