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试剂描述：

产品名称：PTP Inhibitor I

产品别名：4-Hydroxyphenacyl bromide; α-Bromo-4-hydroxyacetophenone

CAS号：2491-38-5

英文别名：4-Hydroxyphenacyl bromide; α-Bromo-4-hydroxyacetophenone

分子量：215.04

分子式：C₈H₇BrO₂

纯度：≥98%

外观：Powder

保存方法：Store at -80° C

描述：PTP Inhibitor I is a potent covalent inhibitor of protein tyrosine phosphatases. The compound is found to be cell-permeable and to specifically inhibit SH-PTP1 (SHP-1) and PTP1B (Protein tyrosine phosphatase 1B). It has been observed in human ovarian cancer cells when SHP-1 is inhibited anti-tumor activity is induced. Inhibition of PTPIB has been observed to upregulate the insulin receptor signal transduction pathway. Although PTP inhibitors would prove useful for elucidating PTP signal transduction, selective active site binding has been shown to be difficult to achieve. PTP inhibitor I is utilized in laboratories as a derivatization reagent for High Performance Liquid Chromatography analysis of carboxylic acids.

应用：A potent covalent inhibitor of protein tyrosine phosphatases SHP-1 and PTPIB

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