DDB1 Antibody
Cat#：PL0302512
Isotype:Rabbit Polyclonal IgG
Immunogen：Peptide derived from human DDB1.
Purification: Immunogen affinity purified
Storage Buffer: PBS, pH 7.4(1%BSA and 0.1% Sodium azide)
Background：
This gene encodes the large subunit of DNA damage-binding protein which is a heterodimer composed of a large and a small subunit. This protein functions in nucleotide-excision repair. Its defective activity causes the repair defect in the patients with xeroderma pigmentosum complementation group E (XPE). However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients.
Alternate Names：
DNA damage-binding protein 1; DDB1; DDB-1; ;Damage specific DNA binding protein 1; DDB 1; DDB p127 subunit; DDBa; DNA damage binding protein 1; UV damaged DNA binding factor; UV damaged DNA binding protein 1; UV DDB 1; UV-DDB1; X associated protein 1; XAP 1; XAP1; Xeroderma pigmentosum group E complementing protein; XPCE; XPE; XPE binding factor; XPE-BF.
Specificity Reaction：Hu, Mo, Rat, Chi, Cow, Hor
Application Notes:WB: 1:100-500 E: 1:500-1000 IP: 1:20-100 IHC: 1:100-500 IF: 1:100-500
Storage ：
Store at –20ºC for one year. Avoid repeated freeze-thaw cycles. At 4ºC for 2-3 weeks after reconstituted.
This product for research use only, not for use in humans, therapeutic or diagnostic procedures.
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