关键词：TRAF2抗体;肿瘤坏死因子受体关联因子2抗体;肿瘤坏死因子受体关联因子2;TRAF2; TRAP3; TNF receptor-associated factor 2; E3 ubiquitin-protein ligase TRAF2; Tumor necrosis factor type 2 receptor-associated protein 3

中文名称：肿瘤坏死因子受体关联因子2多克隆抗体/TRAF2 Polyclonal Antibody

英文名称：TRAF2 Polyclonal Antibody

产品说明书：http://www.abbkine.cn/datasheet/ABP52635.pdf

产品描述：兔抗-肿瘤坏死因子受体关联因子2 多克隆抗体

TNF receptor-associated factor 2 encoded by TRAF2 is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs， and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined.

Abbkine致力于为全球生命科学研究和医疗发展提供前沿的产品和技术。Abbkine设计、开发、生产并销售了一系列独特的产品，包括生命科学领域研究相关的抗体、研究试剂以及细胞功能分析产品以及蛋白纯化产品。Abbkine的产品为科学研究中的挑战提供卓有成效的解决方案，从而为全球的科学家节省时间并提高研究效率。