| 供应商 | 上海联迈生物工程有限公司 |
| 数量 | 大量 |
| 靶点 | 详见说明书 |
| 级别 | 1 |
| 目录编号 | LM-13712R-FITC |
| 克隆性 | 多克隆 |
| 抗原来源 | Rabbit |
| 保质期 | 1年 |
| 抗体英文名 | Anti-TIN-Ag/FITC |
| 抗体名 | Anti-TIN-Ag/FITC |
| 标记物 | FITC标记 |
| 宿主 | Human, Mouse, Rat, Cow, Horse, Sheep, |
| 适应物种 | Human, Mouse, Rat, Cow, Horse, Sheep, |
| 免疫原 | 详见说明书 |
| 亚型 | IGg |
| 形态 | 粉末、液体、冻干粉 |
| 应用范围 | ICC=1:50-200 IF=1:50-200 |
| 浓度 | 1mg/ml |
| 保存条件 | -20 °C |
| 规格 | 100ul |
| 英文名称 | Anti-TIN-Ag/FITC |
| 中文名称 | FITC标记的肾小管间质肾炎抗原抗体 |
| 别 名 | TINAG; TIN AG; TIN-Ag; TIN1; TIN2; TINAG; TINAG_HUMAN; Tubulointerstitial nephritis antigen. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 免疫学 信号转导 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Cow, Horse, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 55kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human TIN-Ag |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Mediates adhesion of proximal tubule epithelial cells via integrins alpha3-beta1 and alphaV-beta3. This is a non catalytic peptidase C1 family protein. Function: Mediates adhesion of proximal tubule epithelial cells via integrins alpha3-beta1 and alphaV-beta3. This is a non catalytic peptidase C1 family protein. Subcellular Location: Secreted; extracellular space; extracellular matrix; basement membrane. Tissue Specificity: Expressed in the kidney cortex, small intestine and cornea. Post-translational modifications: It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability, thus 2 alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both. DISEASE: Initially observed in the Bowman capsule during early glomerular capillary loop formation in the kidney. In more developmentally mature glomeruli, following transition from early to mid-capillary loop stage, expression is higher in the proximal tubular basement membrane than in the distal basement membrane and Bowman capsule. Similarity: Belongs to the peptidase C1 family. Contains 1 SMB (somatomedin-B) domain. Database links: Entrez Gene: 27283 Human Omim: 606749 Human SwissProt: Q9UJW2 Human Unigene: 127011 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 肾小管间质性肾炎抗原(tubulointerstitial nephritis antigen,TINag)是一种主要表达在肾脏近曲小管基底膜,少部分表达在远端小管和鲍曼囊以及肠黏膜基底膜的膜糖蛋白,TINag与Ⅳ型胶原蛋白和层粘连蛋白等细胞外基质具有较高的亲和力,对维持小管基底膜的结构与功能具有重要作用. |
