| 数量 | 大量 |
| 供应商 | 上海研卉生物科技有限公司 |
| 英文名 | Recombinant Human FGF-basic (154 a.a.) |
| 规格 | 10ug |
碱性成纤维细胞生长因子bFGF
FGF-basic is one of 23 known members of the FGF family. Proteins of this family play a central role during prenatal development, postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-basic is a non-glycosylated, heparin-binding growth factor that is expressed in the brain, pituitary, kidney, retina, bone, testis, adrenal gland, liver, monocytes, epithelial cells and endothelial cells. FGF-basic signals through FGFR 1b, 1c, 2c, 3c and 4. Recombinant Human FGF-basic is a 17.2 kDa protein consisting of 154 amino acid residues.
Qualified for stem cell use.
Source: E.coli
Synonyms: Fibroblast Growth Factor-basic, FGF-2, HBGF-2, Prostatropin
AA Sequence: AAGSITTLPA LPEDGGSGAF PPGHFKDPKR LYCKNGGFFL RIHPDGRVDG VREKSDPHIK LQLQAEERGV VSIKGVCANR YLAMKEDGRL LASKCVTDEC FFFERLESNN YNTYRSRKYT SWYVALKRTG QYKLGSKTGP GQKAILFLPM SAKS
Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses.
Biological Activity: Determined by a cell proliferation assay using Balb/c 3T3 cells. The expected ED50 is ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1 x 107 units/mg.
Calculated Molecular Weight: 17.2 kDa
Accession Number: P09038
Gene ID: 2247
| First Author | Title | Citation | Date | Pubmed |
|---|---|---|---|---|
| Milleret, V | Rational design and in vitro characterization of novel dental implant and abutment surfaces for balancing clinical and biological needs. | ACS Medicinal Chemistry Letters; 21 Suppl 1 pg15-24 | 1 Mar 2019 | 30809940 Show Usages |
| Rosa, S | Functional characterization of iPSC-derived arterial- and venous-like endothelial cells. | ACS Medicinal Chemistry Letters; 9(1) pg3826 | 7 Mar 2019 | 30846769 Show Usages |
| Misawa, T | Close association of water channel AQP1 with amyloid-beta deposition in Alzheimer disease brains. | Acta Neuropathologica; 116(3) pg247-60 | 0 Sep 2008 | 18509662 Show Usages |
| Brett, J O | The microRNA cluster miR-106b~25 regulates adult neural stem/progenitor cell proliferation and neuronal differentiation. | Aging; 3(2) pg108-24 | 0 Feb 2011 | 21386132 Show Usages |
| Bogomazova, A N | Error-prone nonhomologous end joining repair operates in human pluripotent stem cells during late G2. | Aging; 3(6) pg584-96 | 0 Jun 2011 | 21685510 Show Usages |
| Brazel, C Y | Sox2 expression defines a heterogeneous population of neurosphere-forming cells in the adult murine brain. | Aging Cell; 4(4) pg197-207 | 0 Aug 2005 | 16026334 Show Usages |
| Liu, S | The PI3K-Akt pathway inhibits senescence and promotes self-renewal of human skin-derived precursors in vitro. | Aging Cell; 10(4) pg661-74 | 0 Aug 2011 | 21418510 Show Usages |
| Mohan, S | High glucose-induced IKK-Hsp-90 interaction contributes to endothelial dysfunction. | American Journal of Physiology. Cell Physiology; 296(1) pgC182-92 | 0 Jan 2009 | 18945937 Show Usages |
| Cocks, H C | Role and regulation of the fibroblast growth factor axis in human thyroid follicular cells. | American Journal of Physiology. Endocrinology and Metabolism; 285(3) pgE460-9 | 0 Sep 2003 | 12746216 Show Usages |
| Chailley-Heu, B | FGF-18 is upregulated in the postnatal rat lung and enhances elastogenesis in myofibroblasts. | American Journal of Physiology. Lung Cellular and Molecular Physiology; 288(1) pgL43-51 | 0 Jan 2005 | 15447937 Show Usages |
| Tamò, L | Generation of an alveolar epithelial type II cell line from induced pluripotent stem cells. | American Journal of Physiology. Lung Cellular and Molecular Physiology; 315(6) pgL921-L932 | 1 Dec 2018 | 30211653 Show Usages |
| Trapp, V | Anti-angiogenic effects of resveratrol mediated by decreased VEGF and increased TSP1 expression in melanoma-endothelial cell co-culture. | Angiogenesis; 13(4) pg305-15 | 0 Dec 2010 | 20927579 Show Usages |
| Cass, W A | Protection by GDNF and other trophic factors against the dopamine-depleting effects of neurotoxic doses of methamphetamine. | Annals of the New York Academy of Sciences; 1074 pg272-81 | 0 Aug 2006 | 17105923 Show Usages |
| Scharbrodt, W | Basic fibroblast growth factor-induced endothelial proliferation and NO synthesis involves inward rectifier K+ current. | Arteriosclerosis, Thrombosis, and Vascular Biology; 24(7) pg1229-33 | 0 Jul 2004 | 15130912 Show Usages |
| Vincent, T L | Basic fibroblast growth factor mediates transduction of mechanical signals when articular cartilage is loaded. | Arthritis and Rheumatism; 50(2) pg526-33 | 0 Feb 2004 | 14872495 Show Usages |
| Nakano, K | Induction of RANKL expression and osteoclast maturation by the binding of fibroblast growth factor 2 to heparan sulfate proteoglycan on rheumatoid synovial fibroblasts. | Arthritis and Rheumatism; 50(8) pg2450-8 | 0 Aug 2004 | 15334457 Show Usages |
| Sawaji, Y | Fibroblast growth factor 2 inhibits induction of aggrecanase activity in human articular cartilage. | Arthritis and Rheumatism; 58(11) pg3498-509 | 0 Nov 2008 | 18975307 Show Usages |
| Guardia Clausi, M | Apotransferrin-induced recovery after hypoxic/ischaemic injury on myelination. | ASN Neuro; 2(5) pge00048 | 19 Nov 2010 | 21113232 Show Usages |
| Yanagisawa, M | Expression of GD2 and GD3 gangliosides in human embryonic neural stem cells. | ASN Neuro; 3(2) | 7 Apr 2011 | 21395555 Show Usages |
| Wang, X | FGFR3/fibroblast growth factor receptor 3 inhibits autophagy through decreasing the ATG12-ATG5 conjugate, leading to the delay of cartilage development in achondroplasia. | Autophagy; 11(11) pg1998-2013 | 2 Nov 2015 | 26491898 Show Usages |
| Penvose, A | Sca-1 is involved in the adhesion of myosphere cells to αVβ3 integrin. | Biology Open; 1(9) pg839-47 | 15 Sep 2012 | 23213478 Show Usages |
| Freeman, I | The influence of the sequential delivery of angiogenic factors from affinity-binding alginate scaffolds on vascularization. | Biomaterials; 30(11) pg2122-31 | 0 Apr 2009 | 19152972 Show Usages |
| Pabbruwe, M B | Induction of cartilage integration by a chondrocyte/collagen-scaffold implant. | Biomaterials; 30(26) pg4277-86 | 0 Sep 2009 | 19539365 Show Usages |
| Khan, I M | In vitro growth factor-induced bio engineering of mature articular cartilage. | Biomaterials; 34(5) pg1478-87 | 0 Feb 2013 | 23182922 Show Usages |
| Gaviraghi, M | Pancreatic cancer spheres are more than just aggregates of stem marker-positive cells. | Bioscience Reports; 31(1) pg45-55 | 0 Feb 2011 | 20426768 Show Usages |
| Ramalingam, R | E1(-)E4(+) adenoviral gene transfer vectors function as a "pro-life" signal to promote survival of primary human endothelial cells. | Blood; 93(9) pg2936-44 | 1 May 1999 | 10216088 Show Usages |
| Collen, A | Membrane-type matrix metalloproteinase-mediated angiogenesis in a fibrin-collagen matrix. | Blood; 101(5) pg1810-7 | 1 Mar 2003 | 12393408 Show Usages |
| Marodon, G | Specific transgene expression in human and mouse CD4+ cells using lentiviral vectors with regulatory sequences from the CD4 gene. | Blood; 101(9) pg3416-23 | 1 May 2003 | 12511423 Show Usages |
| Peng, H | Identification of a binding site on human FGF-2 for fibrinogen. | Blood; 103(6) pg2114-20 | 15 Mar 2004 | 14630795 Show Usages |
| Ingram, D A | Identification of a novel hierarchy of endothelial progenitor cells using human peripheral and umbilical cord blood. | Blood; 104(9) pg2752-60 | 1 Nov 2004 | 15226175 Show Usages |
| Sahni, A | Stimulation of endothelial cell proliferation by FGF-2 in the presence of fibrinogen requires alphavbeta3. | Blood; 104(12) pg3635-41 | 1 Dec 2004 | 15297314 Show Usages |
| Secchiero, P | TRAIL counteracts the proadhesive activity of inflammatory cytokines in endothelial cells by down-modulating CCL8 and CXCL10 chemokine expression and release. | Blood; 105(9) pg3413-9 | 1 May 2005 | 15644410 Show Usages |
| Ulyanova, T | VCAM-1 expression in adult hematopoietic and nonhematopoietic cells is controlled by tissue-inductive signals and reflects their developmental origin. | Blood; 106(1) pg86-94 | 1 Jul 2005 | 15769895 Show Usages |
| Zhou, H | T cell-mediated suppression of angiogenesis results in tumor protective immunity. | Blood; 106(6) pg2026-32 | 15 Sep 2005 | 15920006 Show Usages |
| Zijlstra, A | Proangiogenic role of neutrophil-like inflammatory heterophils during neovascularization induced by growth factors and human tumor cells. | Blood; 107(1) pg317-27 | 1 Jan 2006 | 16174763 Show Usages |
| Anjos-Afonso, F | Nonhematopoietic/endothelial SSEA-1+ cells define the most primitive progenitors in the adult murine bone marrow mesenchymal compartment. | Blood; 109(3) pg1298-306 | 1 Feb 2007 | 17003364 Show Usages |
| Tober, J | The megakaryocyte lineage originates from hemangioblast precursors and is an integral component both of primitive and of definitive hematopoiesis. | Blood; 109(4) pg1433-41 | 15 Feb 2007 | 17062726 Show Usages |
| Nakayama, T | FGF2 posttranscriptionally down-regulates expression of SDF1 in bone marrow stromal cells through FGFR1 IIIc. | Blood; 109(4) pg1363-72 | 15 Feb 2007 | 17077327 Show Usages |
| Nagano, M | Identification of functional endothelial progenitor cells suitable for the treatment of ischemic tissue using human umbilical cord blood. | Blood; 110(1) pg151-60 | 1 Jul 2007 | 17379743 Show Usages |
| Davis, R P | Targeting a GFP reporter gene to the MIXL1 locus of human embryonic stem cells identifies human primitive streak-like cells and enables isolation of primitive hematopoietic precursors. | Blood; 111(4) pg1876-84 | 15 Feb 2008 | 18032708 Show Usages |
| Zambidis, E T | Expression of angiotensin-converting enzyme (CD143) identifies and regulates primitive hemangioblasts derived from human pluripotent stem cells. | Blood; 112(9) pg3601-14 | 1 Nov 2008 | 18728246 Show Usages |
| Carmona, G | Role of the small GTPase Rap1 for integrin activity regulation in endothelial cells and angiogenesis. | Blood; 113(2) pg488-97 | 8 Jan 2009 | 18805968 Show Usages |
| Klimchenko, O | A common bipotent progenitor generates the erythroid and megakaryocyte lineages in embryonic stem cell-derived primitive hematopoiesis. | Blood; 114(8) pg1506-17 | 20 Aug 2009 | 19478046 Show Usages |
| Kovarova, M | Human embryonic stem cells: a source of mast cells for the study of allergic and inflammatory diseases. | Blood; 115(18) pg3695-703 | 6 May 2010 | 20200352 Show Usages |
| Yu, C | Retinoic acid enhances the generation of hematopoietic progenitors from human embryonic stem cell-derived hemato-vascular precursors. | Blood; 116(23) pg4786-94 | 2 Dec 2010 | 20427702 Show Usages |
| Taylor, S M | Angiogenic factor signaling regulates centrosome duplication in endothelial cells of developing blood vessels. | Blood; 116(16) pg3108-17 | 21 Oct 2010 | 20664058 Show Usages |
| El Haddad, N | Mesenchymal stem cells express serine protease inhibitor to evade the host immune response. | Blood; 117(4) pg1176-83 | 27 Jan 2011 | 21076046 Show Usages |
| Huang, X | Regulated expression of microRNAs-126/126* inhibits erythropoiesis from human embryonic stem cells. | Blood; 117(7) pg2157-65 | 17 Feb 2011 | 21163928 Show Usages |
| Kumano, K | Generation of induced pluripotent stem cells from primary chronic myelogenous leukemia patient samples. | Blood; 119(26) pg6234-42 | 28 Jun 2012 | 22592606 Show Usages |
| Yu, Q C | APELIN promotes hematopoiesis from human embryonic stem cells. | Blood; 119(26) pg6243-54 | 28 Jun 2012 | 22611158 Show Usages |
| Amabile, G | In vivo generation of transplantable human hematopoietic cells from induced pluripotent stem cells. | Blood; 121(8) pg1255-64 | 21 Feb 2013 | 23212524 Show Usages |
| Merling, R K | Transgene-free iPSCs generated from small volume peripheral blood nonmobilized CD34+ cells. | Blood; 121(14) pge98-107 | 4 Apr 2013 | 23386128 Show Usages |
| Gekas, C | CD41 expression marks myeloid-biased adult hematopoietic stem cells and increases with age. | Blood; 121(22) pg4463-72 | 30 May 2013 | 23564910 Show Usages |
| Zhang, H | Fibrocytes represent a novel MDSC subset circulating in patients with metastatic cancer. | Blood; 122(7) pg1105-13 | 15 Aug 2013 | 23757729 Show Usages |
| Traer, E | Ponatinib overcomes FGF2-mediated resistance in CML patients without kinase domain mutations. | Blood; 123(10) pg1516-24 | 6 Mar 2014 | 24408322 Show Usages |
| Hsu, J | Reprogramming identifies functionally distinct stages of clonal evolution in myelodysplastic syndromes. | Blood; 134(2) pg186-198 | 11 Jul 2019 | 31010849 Show Usages |
| Wehr, M C | Analysis of transient phosphorylation-dependent protein-protein interactions in living mammalian cells using split-TEV. | BMC Biotechnology; 8 pg55 | 13 Jul 2008 | 18620601 Show Usages |
| Melotti, A | In vitro and in vivo characterization of highly purified human mesothelioma derived cells. | BMC Cancer; 10 pg54 | 22 Feb 2010 | 20175889 Show Usages |
| Amoureux, M | Polysialic acid neural cell adhesion molecule (PSA-NCAM) is an adverse prognosis factor in glioblastoma, and regulates olig2 expression in glioma cell lines. | BMC Cancer; 10 pg91 | 10 Mar 2010 | 20219118 Show Usages |
| Cohen, J R | Pituitary adenylyl cyclase activating polypeptide inhibits gli1 gene expression and proliferation in primary medulloblastoma derived tumorsphere cultures. | BMC Cancer; 10 pg676 | 9 Dec 2010 | 21143927 Show Usages |
| Martins-Neves, S R | Therapeutic implications of an enriched cancer stem-like cell population in a human osteosarcoma cell line. | BMC Cancer; 12 pg139 | 4 Apr 2012 | 22475227 Show Usages |
| Monticone, M | Identification of a novel set of genes reflecting different in vivo invasive patterns of human GBM cells. | BMC Cancer; 12 pg358 | 17 Aug 2012 | 22901239 Show Usages |
| Põlajeva, J | miRNA-21 is developmentally regulated in mouse brain and is co-expressed with SOX2 in glioma. | BMC Cancer; 12 pg378 | 29 Aug 2012 | 22931209 Show Usages |
| Põlajeva, J | miRNA-21 is developmentally regulated in mouse brain and is co-expressed with SOX2 in glioma. | BMC Cancer; 12 pg378 | 29 Aug 2012 | 22931209 Show Usages |
| Ogaki, S | An expression profile analysis of ES cell-derived definitive endodermal cells and Pdx1-expressing cells. | BMC Developmental Biology; 11 pg13 | 1 Mar 2011 | 21362171 Show Usages |
| Silber, J | miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells. | BMC Medicine; 6 pg14 | 24 Jun 2008 | 18577219 Show Usages |
| Milner, R | A novel three-dimensional system to study interactions between endothelial cells and neural cells of the developing central nervous system. | BMC Neuroscience; 8 pg3 | 2 Jan 2007 | 17199896 Show Usages |
| Borgs, L | Period 2 regulates neural stem/progenitor cell proliferation in the adult hippocampus. | BMC Neuroscience; 10 pg30 | 27 Mar 2009 | 19327139 Show Usages |
| Montague, P | Subcellular localization of Mayven following expression of wild type and mutant EGFP tagged cDNAs. | BMC Neuroscience; 11 pg63 | 26 May 2010 | 20504342 Show Usages |
| Mamaeva, D | Isolation of mineralizing Nestin+ Nkx6.1+ vascular muscular cells from the adult human spinal cord. | BMC Neuroscience; 12 pg99 | 10 Oct 2011 | 21985235 Show Usages |
| El-Akabawy, G | Implantation of undifferentiated and pre-differentiated human neural stem cells in the R6/2 transgenic mouse model of Huntington's disease. | BMC Neuroscience; 13 pg97 | 9 Aug 2012 | 22876937 Show Usages |
| Hicks, S D | Evaluation of cell proliferation, apoptosis, and DNA-repair genes as potential biomarkers for ethanol-induced CNS alterations. | BMC Neuroscience; 13 pg128 | 25 Oct 2012 | 23095216 Show Usages |
| Techangamsuwan, S | Similar behaviour and primate-like properties of adult canine Schwann cells and olfactory ensheathing cells in long-term culture. | Brain Research; 1240 pg31-8 | 13 Nov 2008 | 18817757 Show Usages |
| Bajo, A M | Bombesin antagonists inhibit proangiogenic factors in human experimental breast cancers. | British Journal of Cancer; 90(1) pg245-52 | 12 Jan 2004 | 14710236 Show Usages |
| Mukherjee, A | Cytotoxic and antiangiogenic activity of AW464 (NSC 706704), a novel thioredoxin inhibitor: an in vitro study. | British Journal of Cancer; 92(2) pg350-8 | 31 Jan 2005 | 15655539 Show Usages |
