Anti-ECD antibody

Cat. No. JC125470
Package 25 μl/100 μl/200 μl
Storage -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Product overview
Description Anti-ECD rabbit polyclonal antibody
Applications ELISA, WB, IHC 
Immunogen Fusion protein of human ECD
Reactivity Human
Content 0.6 mg/ml
Host species Rabbit
Ig class Immunogen-specific rabbit IgG
Purification Antigen affinity purification

Anti-ECD antibody
Target information
Symbol ECD
Full name ecdysoneless cell cycle regulator
Synonyms GCR2; SGT1; HSGT1
Swissprot O95905

Target Background
Regulator of p53/TP53 stability and function. Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP (PubMed:16849563, PubMed:23880345). May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes (PubMed:19919181, PubMed:9928932). Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins (PubMed:19640839). The cell cycle -regulating function may depend on its RUVBL1-mediated association with the R2TP complex (PubMed:26711270). May play a role in regulation of pre-mRNA splicing (PubMed:24722212).

Anti-ECD antibody
Applications
Immunohistochemistry
Predicted cell location: Cytoplasm or Nucleus
Positive control: Human cervical cancer
Recommended dilution: 25-100 Predicted cell location: Cytoplasm or Nucleus
Positive control: Human thyroid cancer
Recommended dilution: 25-100