产品英文名称：
Recombinant Human Growth Factor Receptor-Bound Protein 2

英文简称:
GRB2

中文名称:
重组人生长因子受体-结合蛋白2

背景资料:
GRB2 is widely expressed and binds the EGFR and contains one SH2 domain and two SH3 domains which form a complex formation with proline-rich regions of other proteins， and its SH2 domain binds tyrosine phosphorylated sequences. GRB2 is related to the Sem5 gene of C.elegans， which is takes part in the signal transduction pathway. GRB2 is an adaptor protein that provides an important link betwGRB2 produced in E.Coli is a single， non-glycosylated polypeptide chain containing 237 amino acids （1-207 a.a.） and having a molecular mass of 27 kDa.GRB2 is expressed with a 20 amino acid His tag at N-Terminus and purified by proprietary chromatographic techniques.n cell surface growth factor receptors and the Ras signaling pathway. Inhibition of GRB2 activity damages developmental processes in a variety of organisms and blocks transformation and proliferation of di大肠杆菌中重组表达erent cell types.

产品描述:
GRB2 produced in E.Coli is a single， non-glycosylated polypeptide chain containing 237 amino acids （1-207 a.a.） and having a molecular mass of 27 kDa.GRB2 is expressed with a 20 amino acid His tag at N-Terminus and purified by proprietary chromatographic techniques.
来源宿主:
大肠杆菌中重组表达

序列:
MGSSHHHHHH SSGLVPRGSH MEAIAKYDFK ATADDELSFK RGDILKVLNE ECDQNWYKAE LNGKDGFIPK NYIEMKPHPW FFGKIPRAKA EEMLSKQRHDGAFLIRESES APGDFSLSVK FGNDVQHFKV LRDGAGKYFL WVVKFNSLNE LVDYHRSTSV SRNQQIFLRD IEQVPQQPTY VQALFDFDPQ EDGELGFRRGDFIHVMDNSD PNWWKGACHG QTGMFPRNYV TPVNRNV.

溶解建议:
Sterile filtered colorless solution. The GRB2 protein solution contains 20mM Tris-HCl， pH-8 and 30% glycerol.

保存建议：
Store at 4℃ if entire vial will be used within 2-4 weeks.Store， frozen at -20℃ for longer periods of time.For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）.Avoid multiple freeze-thaw cycles.
其他简介：

ProSpec是一家全球著名细胞因子蛋白及相关抗体生产和研发品牌。ProSpec的生产和研发工厂位于以色列，专注于蛋白（重组及合成）生产研发，其独有的细菌和哺乳动物表达和蛋白折叠技术使其能在17年内成长为国际一流的科研级蛋白供应商。目前ProSpec可以提供细胞因子，生长因子，激素，信号蛋白，病毒抗原等近800种重组蛋白和100多种抗体，是世界上提供蛋白品种最多的公司之一，领先的生产工艺和规模使其可以提供毫克到克级蛋白，价格优于同类公司。绝大部分产品是天然成熟型蛋白，而不含有标签蛋白。考虑到大部分研究者希望能更灵活地配制蛋白溶液，ProSpec-Tany绝大部分产品没有添加保护剂或盐，这就对工艺提出了更高的要求。同时，ProSpec-Tany绝大部分产品为冻干粉，因此易于运输和保存。
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