本公司提供科研eIF4E真核翻译起始因子4E抗体，抗体质量可靠，订购eIF4E真核翻译起始因子4E抗体请联系在线客服或者销售人员。
抗体参数如下>>>>
中文名称：真核翻译起始因子4E抗体
英文名称：Anti-eIF4E
货号：bs-3621R
抗体来源：兔
克隆类型：多克隆
蛋白分子量：predicted molecular weight: 25kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, dog, pig, hrs, cow, chk, Rb, Danio rerio
测试应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
产品背景介绍：eIF4E, a protein modulates translation of maternal mRNAs in early embryos before the onset of zygotic transcription. eIF4E also influences the overall rate of translation. eIF4E binds to the 7 methyl GTP cap structure of eukaryotic mRNAs. Phosphorylation of eIF4E on serine 209 regulates the affinity of this protein for the 7 methyl GTP cap and/or RNA. Phosphorylation also enhances the interaction of eIF4E with eIF4G, which form a complex known as eIF4F. eIF4E phosphorylation is correlated with increased translational rate in a number of cell types. Several kinases are currently being investigated as potential regulators of eIF4E including PKC and/or the MAP kinase activated Mnk.真核细胞翻译起始因子4E-EIF4E是蛋白合成的一个主要调控因子，它表达量增加会促进多种肿瘤的生长的增值、分化，因此EIF4E是一种非常重要的抗癌药物靶标。eIF-4E是一种涉及核糖体与mRNA帽子结构结合的真核生物翻译起始因子。它以2种形式存在：游离形式（25kDa）和作为多蛋白复合物eIF-4F的一个组分。 eIF-4E 是数量最少的一种起始因子，涉及翻译起始的限速步骤，磷酸化调节蛋白质的生物合成。