产品英文名称：
Recombinant Human V-Ha-ras Harvey Rat Sarcoma Viral Oncogene Homolog

英文简称:
HRAS

中文名称:
重组人v-Ha-ras鼠Harvey肉瘤病毒致癌基因同源物

背景资料:
HRAS is part of the Ras oncogene family， whose members are related to the transforming genes of mammalian sarcoma retroviruses. The products encoded by these genes participate in signal transduction pathways. These proteins can bind GTP and GDP， and they have intrinsic GTPase activity. HRAS go trough a continuous cycle of de- and re-palmitoylation， which mediates its rapid exchange betwHRAS Human Recombinant produced in E.Coli is a single， non-glycosylated， polypeptide chain containing 194 amino acids （1-186 a.a.） and having a molecular mass of 22 kDa. HRAS protein is fused to a 8 amino acid His-Tag at C-terminus and purified by standard chromatography.n the plasma membrane and the Golgi apparatus. Mutations in HRAS result in Costello syndrome， a disease characterized by increased growth at the prenatal stage， growth deficiency at the postnatal stage， predisposition to tumor formation， mental retardation， skin and musculoskeletal abnormalities， distinctive facial appearance and cardiovascular abnormalities. Defects in this HRAS gene are implicated in a range of cancers， including bladder cancer， follicular thyroid cancer， and oral squamous cell carcinoma.

产品描述:
HRAS Human Recombinant produced in E.Coli is a single， non-glycosylated， polypeptide chain containing 194 amino acids （1-186 a.a.） and having a molecular mass of 22 kDa. HRAS protein is fused to a 8 amino acid His-Tag at C-terminus and purified by standard chromatography.
来源宿主:
大肠杆菌中重组表达

序列:
MTEYKLVVVG AGGVGKSALT IQLIQNHFVD EYDPTIEDSY RKQVVIDGET CLLDILDTAG QEEYSAMRDQ YMRTGEGFLC VFAINNTKSF EDIHQYREQI KRVKDSDDVP MVLVGNKCDL AARTVESRQA QDLARSYGIP YIETSAKTRQ GVEDAFYTLV REIRQHKLRK LNPPDESGPG CMSCKCLEHH HHHH.

溶解建议:
Sterile filtered colorless solution. HRAS Human solution containing 20mM Trsi HCL pH-8， 0.1M NaCl， & 20% glycerol.

保存建议：
HRAS Human although stable at 4℃ for 1 week， should be stored desiccated below -18℃. Please prevent freeze thaw cycles.
其他简介：

ProSpec是一家全球著名细胞因子蛋白及相关抗体生产和研发品牌。ProSpec的生产和研发工厂位于以色列，专注于蛋白（重组及合成）生产研发，其独有的细菌和哺乳动物表达和蛋白折叠技术使其能在17年内成长为国际一流的科研级蛋白供应商。目前ProSpec可以提供细胞因子，生长因子，激素，信号蛋白，病毒抗原等近800种重组蛋白和100多种抗体，是世界上提供蛋白品种最多的公司之一，领先的生产工艺和规模使其可以提供毫克到克级蛋白，价格优于同类公司。绝大部分产品是天然成熟型蛋白，而不含有标签蛋白。考虑到大部分研究者希望能更灵活地配制蛋白溶液，ProSpec-Tany绝大部分产品没有添加保护剂或盐，这就对工艺提出了更高的要求。同时，ProSpec-Tany绝大部分产品为冻干粉，因此易于运输和保存。