本公司提供科研GNL1鸟嘌呤核苷酸结合蛋白1抗体，抗体质量可靠，订购GNL1鸟嘌呤核苷酸结合蛋白1抗体请联系在线客服或者销售人员。
抗体参数如下>>>>
中文名称：鸟嘌呤核苷酸结合蛋白1抗体
英文名称：Anti-GNL1
货号：bs-8040R
抗体来源：兔
克隆类型：多克隆
蛋白分子量：predicted molecular weight: 69kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat, cow, pig, monkey
测试应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
产品背景介绍：GNL1 is a nuclear protein that likely acts as a regulator of the histocompatibility cluster. GNL1 and MMR1, the murine homolog, are localized within or close to the MHC class I region and belong to the MMR1/HSR1 GTP-binding protein family. GTPases, such as GNL1, from the MMR1/HSR1 GTP-binding protein subfamily are circularly rearranged G-motifs that play a critical role in maintaining normal cell growth. Deletion of these genes results in severe growth defects with a marked reduction in mature rRNA species and a concomitant accumulation of the 35S pre-rRNA transcript. Deletion also causes the ribosomal protein Rpl25a to fail exportation from the nucleolus. Deletion of any of the G-domain motifs will result in a null phenotype and nuclear/nucleolar localization that lacks the nucleolar export of preribosomes and is accompanied by a distortion of the nucleolar structure. Upon DNA damage GNL1 is phosphorylated by a kinase, possibly Atm or ATR. Function : Possible regulatory or functional link with the histocompatibility cluster.