【Molecular Wt.】37 kDa

【Description】NANOG is a transcription factor critically involved with self-renewal of undifferentiated embryonic stem cells. NANOG is thought to function in concert with other factors such as POU5F1 and SOX2 to establish ESC identity. Overexpression of NANOG in mouse embryonic stem cells causes them to self-renew in the absence of Leukemia inhibitory factor. NANOG overexpression in human embryonic stem cells enables their propagation for multiple passages during which the cells remain pluripotent.

【Species Reactivity】Human;mouse

【Tested applications】WB

【Antibody type】Rabbit polyclonal Antibody

【Immunogen】peptide

【Positive control】NCCIT, F9

【Conjugate】Non-conjugated

【Alternative names】Embryonic stem cell specific homeobox protein (Nanog) antibody
ENK antibody
FLJ12581 antibody
hNanog antibody
Homeobox protein NANOG antibody
Homeobox transcription factor Nanog antibody
homeobox transcription factor Nanog-delta 48 antibody
NANOG antibody
Nanog homeobox antibody
NANOG_HUMAN antibody

【Form】Liquid

【Stroage】Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.

【Stroage Buffer】1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

【Isotype】IgG

【Purity】Immunogen affinity purified

【Subcellular location】Cell nucleus

【Background References】1. "The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells."Mitsui K., Tokuzawa Y., Itoh H., Segawa K., Murakami M., Takahashi K., Maruyama M., Maeda M., Yamanaka S.Cell 113:631-642(2003)
2. "Stem cell pluripotency factor NANOG is expressed in human fetal gonocytes, testicular carcinoma in situ and germ cell tumours."Hoei-Hansen C.E., Almstrup K., Nielsen J.E., Brask Sonne S., Graem N., Skakkebaek N.E., Leffers H., Rajpert-De Meyts E.Histopathology 47:48-56(2005)

【DatasheetURL】http://www.huabio.com/upload/R1108-2.pdf

【Uniprot ID】Q9H9S0

【Raised in】Rabbit

【Clone No.】