产品货号:jlcR6088 英文名称:RASAL1 中文名称:RAS蛋白样激活剂1抗体 别名:GAP1 like protein; MRASAL; RAS GTPase activating protein like; RAS protein activator like 1 (GAP1 like); RAS protein activator like 1; RASAL; Rasal1; rasGAP activating like protein 1; RasGAP-activating-like protein 1; RASGAP1 LIKE; RASL1_HUMAN. 研究领域:肿瘤免疫学信号转导 G蛋白偶联受体 G蛋白信号 抗体来源:Rabbit 克隆类型:Polyclonal 交叉反应: Human, Mouse, Rat, Dog, Horse, Rabbit, 产品应用:WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. 分子量:90kDa 细胞定位:细胞浆 性状:Lyophilized or Liquid 浓度:1mg/ml 免疫原:KLH conjugated synthetic peptide derived from human RASAL1:451-550/805 亚型:IgG 纯化方法:affinity purified by Protein A 储存液:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. 保存条件:Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. PubMed:PubMed 产品介绍background: Ras GTPase activating-like protein (RASAL) or RASAL1 is a member of the GAP1 family, and a Ca2+ sensor responding in-phase to repetitive Ca2+ signals by associating with the plasma membrane and deactivating Ras. It contains a conserved domain structure comprising N-terminal tandem C2 domains, a highly conserved central RasGAP domain, and a C-terminal pleckstrin-homology domain that is associated with a Bruton's tyrosine kinase motif. RASAL, like Ca2+ -promoted Ras inactivator (CAPRI, or RASAL4), is a cytosolic protein that undergoes a rapid translocation to the plasma membrane in response to receptor-mediated elevation in the concentration of intracellular free Ca2+, a translocation that activates its ability to function as a RasGAP. However, unlike RASAL4, RASAL undergoes an oscillatory translocation to the plasma membrane that occurs in synchrony with repetitive Ca2+ spikes.
Function: Probable inhibitory regulator of the Ras-cyclic AMP pathway.
Tissue Specificity: Highly expressed in thyroid and adrenal medulla, lower expression in brain, spinal cord and trachea.
