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| 免疫原 | Purified recombinant full length of human IgM heavy chain protein expressed in E.coli. |
| 亚型 | IgG2a |
| 形态 | 液体 |
| 保存条件 | Store at -20°C. Avoid freeze / thaw cycles. |
| 克隆性 | 单克隆 |
| 适应物种 | Human |
| 目录编号 | K001450M |
| 数量 | 999 |
| 供应商 | 北京索莱宝科技有限公司 |
| 宿主 | Mouse |
| 靶点 | Human IgM |
| 抗体英文名 | Anti-Human IgM Monoclonal Antibody |
| 抗体名 | Human IgM |
| 规格 | 50ul/100ul |
| 英文名称 | Anti-Human IgM Monoclonal Antibody |
|---|---|
| 宿主 | Mouse |
| 别名 | Human IgM |
| 稀释比例 | WB 1:1000. |
| 蛋白分子量 | 75kDa |
| Gene ID | 3507 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 储存液 | Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 纯化方法 | Affinity purification |
| 亚型 | IgG2a |
| 免疫原 | Purified recombinant full length of human IgM heavy chain protein expressed in E.coli. |
| 性状 | 液体 |
| Public Immunogen Range | Purified recombinant full length of human IgM heavy chain protein expressed in E.coli. |
| 亚细胞定位 | Cell membrane Secreted |
| Swiss Prot | P01871 |
| 克隆号 | 3E12-H4-G4 |
| 克隆类型 | Monoclonal Antibody |
| 背景资料 | Immunoglobulins (Ig) are the antigen recognition molecules of B cells. An Ig molecule is made up of 2 identical heavy chains and 2 identical light chains (see MIM 147200) joined by disulfide bonds so that each heavy chain is linked to a light chain and the 2 heavy chains are linked together. Each Ig heavy chain has an N-terminal variable (V) region containing the antigen-binding site and a C-terminal constant (C) region, encoded by an individual C region gene, that determines the isotype of the antibody and provides effector or signaling functions. The heavy chain V region is encoded by 1 each of 3 types of genes: V genes (see MIM 147070), joining (J) genes (see MIM 147010), and diversity (D) genes (see MIM 146910). The C region genes are clustered downstream of the V region genes within the heavy chain locus on chromosome 14. The IGHM gene encodes the C region of the mu heavy chain, which defines the IgM isotype. Naive B cells express the transmembrane forms of IgM and IgD (see IGHD; MIM 1471770) on their surface. During an antibody response, activated B cells can switch to the expression of individual downstream heavy chain C region genes by a process of somatic recombination known as isotype switching. In addition, secreted Ig forms that act as antibodies can be produced by alternative RNA processing of the heavy chain C region sequences. Although the membrane forms of all Ig isotypes are monomeric, secreted IgM forms pentamers, and occasionally hexamers, in plasma |
| 应用 | ELISA |
| 交叉反应 | Human |
| 规格 | 50ul 100ul |
