本公司提供科研NPSR1/GPR154神经肽S受体1/G蛋白偶联受体154抗体，抗体质量可靠，订购NPSR1/GPR154神经肽S受体1/G蛋白偶联受体154抗体请联系在线客服或者销售人员。
抗体参数如下>>>>
中文名称：神经肽S受体1/G蛋白偶联受体154抗体
英文名称：Anti-NPSR1/GPR154
货号：bs-11430R
抗体来源：兔
克隆类型：多克隆
蛋白分子量：predicted molecular weight: 43kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat
测试应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
产品背景介绍：G protein-coupled receptors (GPRs), also known as seven transmembrane receptors, heptahelical receptors or 7TM receptors, comprise a superfamily of proteins that play a role in many different stimulus-response pathways. G protein coupled receptors translate extracellular signals into intracellular signals (G protein activation) and they respond to a variety of signaling molecules, such as hormones and neurotransmitters. GPR154 (G-protein coupled receptor 154), also known as NPSR1 (neuropeptide S receptor), GPRA (G-protein coupled receptor for asthma susceptibility) or PGR14, is a 371 amino acid protein that is thought to play a role in autocrine or paracrine signaling pathways. Ubiquitously expressed, GPR154 exists as nine alternatively spliced isoforms. Defects in the gene encoding GPR154 is the cause of asthma-related traits type 2 (ASRT2). Function : Neuropeptide S receptor 1 (GPR154) is a receptor for Neuropeptide S. It is expressed on the epithelia of several organs including the intestine, and appears to be upregulated in inflammation. It is upregulated in macrophages after antigen challenge and is involved in the pathogenesis of asthma and other IgE-mediated diseases. Subcellular Location : Cell Membrane and Cytoplasmic神经肽S(neuropeptide S,NPS)是2002年发现的一种神经肽,由20个氨基酸组成,通过激活其受体NPSR而发挥作用。NPS/NPSR系统参与调节觉醒和睡眠、焦虑、摄食、免疫等功能。神经肽S（neuropeptide S，NPS），通过激活其同源受体（NPSR），并引发细胞内 Ca2+动员，进而调控失眠和忧虑，具有提高实验动物的清醒程度以及有减少焦虑的作用。