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PCA50941

CAS No. : 136941-85-0

MCE 国际站：PCA50941

产品活性：PCA50941 是 1，4-二氢吡啶衍生物，可用于心血管疾病的研究。

研究领域：Others

作用靶点：Others

In Vitro: PCA50941 (1 μM) shifts the I-V relationship of whole-cell Ca²⁺ currents by about 5-10 mV towards more hyperpolarizing potentials. PCA50941 increases further the K(+)-evoked peak to 655 nM. In the presence of 5 mM Ca²⁺, PCA50941 increases the [Ca²⁺] peaks to 427 nM. PCA50941 potentiates the release of catecholamines from perfused bovine adrenal glands evoked by 30 s pulses of 17.7 mM K⁺ in a manner dependent on the [Ca²⁺]o.

In Vivo: PCA50941 (10-120 μM) by intracoronary injection, causes smaller reductions of coronary blood flow (CBF) in goats. PCA50941 (10-300 μM/min) does not modify CBF nor the other hemodynamic variables recorded by i.v. infusions in 4 goats. Intravenous infusion of PCA50941 (100 microg/min) reverses the hemodynamic variables from the shock state to control values within 20 min in 5 of 6 animals.

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