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试剂描述：

产品名称：Recombinant Human IRF-3

产品别名：重组人干扰素调节因子-3；Recombinant Human Interferon Regulatory Factor-3

CAS号：见爱必信官网

英文别名：Recombinant Human Interferon Regulatory Factor-3

分子量：见爱必信官网

分子式：见爱必信官网

纯度：0.95

外观：Sterile Filtered colorless solution（1mg/ml in phosphate-buffered saline (PBS), pH 7.4.）

保存方法：Liquid Interferon although stable at 10°C for 1 week, should be stored below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

描述：

Members of the Interferon regulatory factor (IRF) family regulate gene expression critical to immune response, hemopoiesis, and proliferation. IRF-3 is a member of the IRF family, and is distinct from other family members. Its transcriptional activity is regulated solely by posttranslational modifications. It plays a crucial role in activation of innate immunity and inflammation in response to viral infection. IRF-3 mediates interferon-stimulated response element (isre) promoter activation. Functions as a molecular switch for antiviral activity. Dsrna generated during the course of an viral infection leads to IRF3 phosphorylation on the c-terminal serine/threonine cluster. This induces a conformational change, leading to its dimerization, nuclear localization and association with creb binding protein (crebbp) to form dsrna-activated factor 1 (draf1), a complex which activates the transcription of genes under the control of isre. The complex binds to the ie and prdiii regions on the ifn-alpha and ifn-beta promoters respectively. IRF-3 does not have any transcription activation domains.

应用：见爱必信官网

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