Sciencell公司产品由上海中乔新舟生物科技有限公司优质供应

美国ScienCell研究实验室（www.sciencellonline.com）成立于1999年，公司总部位于美国加州的圣地亚哥。主要致力
于实验室科研用原代细胞、原代细胞专用培养基、原代细胞无血清培养基、干细胞、干细胞培养基、干细胞无血清培养
基的研究和开发，在全球拥有众多客户。在国内销售15年来，很多老师应用其产品发表了高质量的SCI文章，且有着极高
的文献引用率。凭借着严格的质控和优秀的产品品质，深受广大科研工作者的信赖。

ScienCell研究实验室生产的原代细胞、原代细胞专用培养基都经过了严格的质量控制，细胞纯度可达98％。其中包括21
种人体正常细胞系统，90多种不同细胞类型。大多数细胞在全球唯有ScienCell实验室能够成功分离，产品质量过硬。
确保了实验结果的重复性和连贯性。

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人真皮淋巴管内皮细胞（Human Dermal Lymphatic Endothelial Cells）

货号：2010

淋巴系统是免疫系统的重要组成部分。维持体内稳定，它属于血管系统，但也有其独立的功能。淋巴系统循环使液
体和大分子从组织回到血液。在调节体液、蛋白和组织压力平衡等方面有着重要的作用。虽然毛细淋巴管内皮细胞
与血管内皮细胞有多种的共同特点，但其特殊的结构特点表现其特殊功能。毛细淋巴管缺少壁层细胞，表现为基底
膜不完整或缺失。淋巴管内皮细胞特征有内陷、胞质囊和重叠的细胞间连接。毛细淋巴管最显著的特征之一就是它
的整合作用，即通过弹性纤维的丝条连接细胞外基质。

人表皮淋巴内皮细胞(HDLEC)提取于人真皮组织，原代冻存。每管含有细胞数>5×105 cells/ml，此细胞通过
Podoplanin , Lyve1. 和CD31免疫荧光染色验证，经测试不含有HIV-1、HBV、HCV、支原体、细菌、酵母和真菌。
细胞可以达到15倍增。

Discription

The lymphatic system is an essential part of the immune system. It serves distinct yet complementary
function with the blood vascular system in maintaining tissue homeostasis. The lymphatic system returns
fluid and macromolecules from the tissues back into blood circulation and, thus, plays a vital role in the
regulation of fluid, protein, and pressure equilibrium in tissues [1]. Although lymphatic capillary endothelial
cells have many properties in common with the endothelium of blood vessels, they also have distinct
structural characteristics reflecting their specific functions. Lymphatic capillaries lack mural cells and are
characterized by an incomplete or absent basement membrane [2]. Lymphatic endothelium typically contains
numerous invaginations and cytoplasmic vesicles as well as characteristic overlapping intercellular junctions [3].
One of the most striking characteristics of the lymphatic capillary is its integration within the interstitium which
is connected to the extracellular matrix by fine strands of elastic fibers.

HDLEC from ScienCell Research Laboratories are isolated from human dermal tissue. HDLEC are cryopreserved
on passage one (immediately after purification) and delivered frozen. Each vial contains >5 x 105 cells in 1 ml
volume. HDLEC are characterized by immunofluorescent method with antibodies to CD31, podoplanin and Lyve1.
HDLEC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi. HDLEC are guaranteed to further
expand for 15 population doublings at the conditions provided by ScienCell Research Laboratories.

Reference
[1] Swerlick, R. A and Lawley, T. J. (1993) Role of microvascular endothelial cells in inflammation. J. Invest.
Dermatol. 100:111S.
[2] Springer, T. (1994) Traffic signals for lymphocyte recirculation and leukocyte emigration. Cell 76:301.
[3] Aird, W. C. (2004) Endothelial cell heterogeneity. Crit. Care Med. 31(4):S221-30.
[4] Chang, E., Yang, J., Nagavarapu, U. and Herron, S. (2004) Aging and survival of cutaneous microvasculature.
J. Invest. Dermatol. 118:752.

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