O位N-乙酰葡萄糖胺OGT抗体价格价格,详情介绍-960化工网

O位N-乙酰葡萄糖胺OGT抗体价格

价格：¥1000 - 3500

品牌：上海博湖

产地：进口、国产

最新更新日期：2021-09-29 18:54

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公司：上海博湖生物科技有限公司

联系人：韩丽君

联系电话： 18117197628 021-57763112

联系邮箱：3004987436@qq.com

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产品属性

抗体名	O位N-乙酰葡萄糖胺OGT抗体价格

抗体英文名

Anti-OGT/O-GlcNAc transferase

靶点

详见说明书

浓度

1mg/1ml

应用范围	WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200

宿主

详见说明书

供应商

上海博湖

数量

大量

级别

详见说明书

目录编号

详见说明书

抗原来源

Rabbit

保质期

详见说明书

适应物种

详见说明书

标记物

详见说明书

克隆性

多克隆

保存条件	Store at -20 °C

形态

大量

亚型

IgG

免疫原	KLH conjugated synthetic peptide derived from human O-GlcNAc transferase

规格	0.2ml/200μg

产品说明

中文名称O位N-乙酰葡萄糖胺OGT抗体价格
英文名称 Anti-OGT/O-GlcNAc transferase
别名 HRNT1; MGC22921; O-GlcNAc transferase; O GlcNAc; O-Linked N-Acetylglucosamine Transferase; O GlcNAc transferase p110 subunit; O GlcNAc transferase subunit p110; O linked N acetylglucosamine (GlcNAc) transferase (UDP N acetylglucosamine:polypeptide N acetylglucosaminyl transferase); O linked N acetylglucosamine transferase 110 kDa subunit; O-GlcNAc transferase subunit p110; O-linked N-acetylglucosamine transferase 110 kDa subunit; OGT; OGT1_HUMAN; UDP N acetylglucosamine peptide N acetylglucosaminyltransferase 110 kDa subunit; UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit; Uridinediphospho N acetylglucosamine:polypeptide beta N acetylglucosaminyl transferase.
O位N-乙酰葡萄糖胺OGT抗体价格是用于化学反应、分析化验、研究实验、教学实验、化学配方使用的纯净化学品，产品品质卓越，价格实惠，多种规格供应，售后完善。

浓度 1mg/1ml
规格 0.2ml/200μg
抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Human, Mouse, Rat, Cow
产品类型一抗
研究领域神经生物学信号转导转录调节因子 Alzheimer's
蛋白分子量 predicted molecular weight: 117kDa
性状 Lyophilized or Liquid
免疫原 KLH conjugated synthetic peptide derived from human O-GlcNAc transferase
亚型 IgG
纯化方法 affinity purified by Protein A
储存液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

O位N-乙酰葡萄糖胺OGT抗体价格产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 Addition of nucleotide-activated sugars directly onto the polypeptide through O-glycosidic linkage with the hydroxyl of serine or threonine. Mediates the O-glycosylation of MLL5 and HCFC1. Promotes proteolytic maturation of HCFC1. Since both phosphorylation and glycosylation compete for similar serine or threonine residues, the two processes may compete for sites, or they may alter the substrate specificity of nearby sites by steric or electrostatic effects. O-GlcNAc transferase has been purified from rat liver. It exists as a heterotrimeric complex with two subunits of the same molecular mass and one shorter subunit. Both polypeptides are related; the short subunit band is either a proteolytic product of the polypeptide or the product of an alternative translation start site. O-GlcNAc transferase is expressed as multiple transcripts that are present in different amounts in various human tissues, with the highest levels of expression in pancreas. Immunofluorescence of human cells expressing rat O-GlcNAc transferase indicated that it is present in both the nucleus and cytosol. HeLa cells expressing O-GlcNAc transferase do not survive well during prolonged incubations, suggesting that this protein may be toxic to the cells.
Function : Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in cytoplasmic and nuclear proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc). Glycosylates a large and diverse number of proteins including histone H2B, AKT1, MLL5, MAPT/TAU and HCFC1. Can regulate their cellular processes via cross-talk between glycosylation and phosphorylation or by affecting proteolytic processing. Involved in insulin resistance in muscle and adipocyte cells via glycosylating insulin signaling components and inhibiting the 'Thr-308' phosphorylation of AKT1, enhancing IRS1 phosphorylation and attenuating insulin signaling. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues.
Isoform 2, the mitochondrial isoform (mOGT), is cytotoxic and triggers apoptosis in several cell types including INS1, an insulinoma cell line.
Subunit : Heterotrimer; consists of one 78 kDa subunit and two 110 kDa subunits dimerized via TPR repeats 6 and 7. Interacts (via TPR repeats 6 and 7) with ATXN10 (By similarity). Component of the MLL5-L complex, at least composed of MLL5, STK38, PPP1CA, PPP1CB, HCFC1, PPP1CC and ACTB. Component of a THAP1/THAP3-HCFC1-OGT complex. Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1. Interacts directly with HCFC1; the interaction O-glycosylates HCFC1, regulates its proteolytic processing and transcriptional activity and, in turn, stabilizes OGT in the nucleus. Interacts (via TPRs 1-6) with SIN3A; the interaction mediates transcriptional repression in parallel with histone deacetylase.
Subcellular Location : Isoform 2: Mitochondrion. Membrane. Note=Associates with the mitochondrial inner membrane. Isoform 3: Cytoplasm. Nucleus. Cell membrane. Note=Mostly in the nucleus. Retained in the nucleus via interaction with HCFC1. After insulin induction, translocated from the nucleus to the cell membrane via phophatidylinisotide binding. Colocalizes with AKT1 at the plasma membrane. Isoform 4: Cytoplasm. Nucleus.
Tissue Specificity : Highly expressed in pancreas and to a lesser extent in skeletal muscle, heart, brain and placenta. Present in trace amounts in lung and liver.
Post-translational modifications : Ubiquitinated, leading to its proteasomal degradation.
DISEASE : Note=Regulation of OGT activity and altered O-GlcNAcylations are implicated in diabetes and Alzheimer disease. O-GlcNAcylation of AKT1 affects insulin signaling and, possibly diabetes. Reduced O-GlcNAcylations and resulting increased phosphorylations of MAPT/TAU are observed in Alzheimer disease (AD) brain cerebrum.
Similarity : Belongs to the O-GlcNAc transferase family.
Contains 13 TPR repeats.

O位N-乙酰葡萄糖胺OGT抗体价格具有全、新、优、品、好四大特点：
全：公司提供上万种产品，涵盖了生物试剂，elisa试剂盒，标准品，培养基，原装耗材，抗体、培养基、ATCC细胞等，基本上各种科研所需产品在我司都能找到。
新：产品更新速度较快，基本上每周都有新产品出现。
优：产品质量好，投诉比较少。
好：我公司具有优质的技术团队，产品一旦售出，实验过程中遇到困难可提供在线技术咨询。使您使用产品时没有任何的后顾之忧。
我们提供的标记服务，可根据您科研的需求，满足您的需要，质量保证，价格合理。
一、标记流程
委托标记服务，请下载并详细填写《委托标记申请单》，待我公司标记室技术人员研究、确认后答复，并办理委托标记事宜。
二、各种标记物制备的收费标准（RMB）
我们不但提供抗体和大分子蛋白的标记服务，还提供小分子多肽及小分子蛋白的各种标记服务，提供标记化合物的服务（此化合物必须适用于标记），价格另议。
一抗和二坑的区别：
第一抗体就是平常所说的抗体，即能和抗原特异性结合。
第二抗体是能和抗体结合的，即抗体的抗体。主要用于检测抗体的存在。
一抗是针对抗原的抗体，二抗是针对一抗的抗体。即抗体也可以充当抗原刺激机体产生抗体。也就是说，抗原进入机体刺激机体免疫系统产生免疫应答，由B细胞可以产生与相应抗原发生特异性结合的特殊蛋白质。
一抗二抗都是一种可以特异结合别的物质的基团，而且一抗可以至少结合两种其他基团（底物和二抗）。
一抗：可以特异结合底物，就是识别出我们想要检测的东西。一抗和底物结合与否用肉眼是看不出来的。
二抗：可以和一抗结合，并带有可以被检测出的标记(如带荧光、放射性、化学发光或显色基团），作用是检测一抗。如果一抗自己带有可以被检测出的标记(如带荧光、放射性、化学发光或显色基团），则不需要二抗。但这样成本很高，因为一种一抗只识别一种底物。所以如今的设计一般是二抗带上可检测标记，再来检测一抗。而一抗识别底物。这样，当一抗结合到底物上，就可以通过二抗检测出来。

信号通路Wnt6抗体 Anti-Wnt6 WB IHC-P IHC-F IF 100ul
WD重复膜蛋白61抗体 Anti-WDR61 WB IHC-P IHC-F IF 100ul
Wnt1信号通路蛋白3抗体 Anti-WISP3 WB IHC-P IHC-F IF 100ul
湿疹血小板减少伴免疫缺陷综合征相关蛋白抗体 Anti-WASP WB IHC-P IHC-F IF 100ul
WDR68蛋白抗体 Anti-WDR68 WB IHC-P IHC-F IF 100ul
3号染色体开放阅读框33抗体 Anti-C3orf33 WB IHC-P IHC-F IF 100ul
3号染色体开放阅读框39抗体 Anti-C3orf39 WB IHC-P IHC-F IF 100ul
3号染色体开放阅读框59抗体 Anti-C3orf59 WB IHC-P IHC-F IF 100ul
5号染色体开放阅读框51抗体 Anti-C5orf51 WB IHC-P IHC-F IF 100ul
3号染色体开放阅读框70抗体 Anti-C3orf70 WB IHC-P IHC-F IF 100ul
RAB3-GTP酶激活蛋白催化亚单位2抗体 Anti-RAB3GAP2 WB IHC-P IHC-F IF 100ul
维诱导蛋白1抗体 Anti-RAI1 WB IHC-P IHC-F IF 100ul
环指蛋白13抗体 Anti-RNF13 WB IHC-P IHC-F IF 100ul
环指蛋白15抗体 Anti-RNF15 WB IHC-P IHC-F IF 100ul
金属蛋白酶抑制因子RECK抗体 Anti-RECK WB IHC-P IHC-F IF 100ul
中国仓鼠卵巢细胞;CTLA4 Ig-24
人肾透明细胞癌;Caki-1
IGF2BP2 Others Human 人 IGF2BP2 / IMP2 / p62 杆状病毒-昆虫细胞裂解液 (阳性对照)
NK-92细胞，人恶性非霍奇金淋巴瘤患者的自然杀伤细胞人肝癌细胞系,Hep-3B细胞 CL-0184PANC-1(人胰腺癌细胞)5×106cells/瓶×2
晶状体上皮细胞Many types of cells包装：5 × 105次方(1ml)
SLAMF1 Others Human 人 CD150 人细
人胚胎皮肤成纤维细胞;HES
SCN2B Others Human 人 SCN2B 人细胞裂解液 (阳性对照)
C57BL/6小鼠胚胎干细胞 C57BL/6 mouse embryonic stem cells
RPMI-8226细胞，人多发性骨髓瘤细胞单核细胞增生李斯特氏菌 SVT转化人脐静脉内皮细胞;PUMC-HUVEC-T1
TT(人甲状腺导管癌细胞) 5×106cells/瓶×2
HSC-T6(大鼠肝星形细胞) 5×106cells/瓶×2 hDPSCs, 人前磨牙牙髓干细胞人原胚肾转化细胞;293 Ad5
O位N-乙酰葡萄糖胺OGT抗体价格中国仓鼠卵巢细胞;CTLA4 Ig-24
人肾透明细胞癌;Caki-1
IGF2BP2 Others Human 人 IGF2BP2 / IMP2 / p62 杆状病毒-昆虫细胞裂解液 (阳性对照)
NK-92细胞，人恶性非霍奇金淋巴瘤患者的自然杀伤细胞人肝癌细胞系,Hep-3B细胞 CL-0184PANC-1(人胰腺癌细胞)5×106cells/瓶×2
晶状体上皮细胞Many types of cells包装：5 × 105次方(1ml)
SLAMF1 Others Human 人 CD150 人细