产品英文名称：
Human Alpha-2-HS-Glycoprotein
英文简称:
Fetuin-A
中文名称:
人胎球蛋白A
背景资料:
Fetuin is a liver-produced negative acute phase protein composed of two subunits， the A and B chains.Fetuin homologs have bn identified in several species including rat， shp， pig， rabbit， guinea pig， cattle， mouse and human. Multiple physiological roles for these homologs have bn suested， including ability to bind to hydroxyapatite crystals and to specifically inhibit the tyrosine kinase （TK） activity of the insulin receptor （IR）.Fetuin-A （alpha2-Heremans-Schmid glycoprotein； AHSG） is an important circulating inhibitor of calcification in vivo， and is downregulated during the acute-phase response.Sera from patients on long-term dialysis with low AHSG concentrations showed impaired ex-vivo capacity to inhibit CaxPO4 precipitation.Fetuin may influence the resolution of inflammation by modulating the phagocytosis of apoptotic cells by macrophages.ASHG blocks TGF-beta-dependent signaling in osteoblastic cells， and mice lacking ASHG display growth plate defects， increased bone formation with age， and enhanced cytokine-dependent osteogenesis.
产品描述:
来源宿主:
人血浆中提取纯化
序列:
溶解建议:
Filtered White lyophilized （freeze-dried） powder. Filtered （0.4um） and lyophilized from 0.5 mg/ml in PBS pH 7.4. It is recommended to add deionized water to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. Product is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.
保存建议：
Store the lyophilized protein at -20℃. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4℃ for a limited period of time； it does not show any change after two weeks at 4℃. The lyophilized protein remains stable until the expiry date when stored at -20℃.
其他简介：
ProSpec是一家全球著名细胞因子蛋白及相关抗体生产和研发品牌。ProSpec的生产和研发工厂位于以色列，专注于蛋白（重组及合成）生产研发，其独有的细菌和哺乳动物表达和蛋白折叠技术使其能在17年内成长为国际一流的科研级蛋白供应商。目前ProSpec可以提供细胞因子，生长因子，激素，信号蛋白，病毒抗原等近800种重组蛋白和100多种抗体，是世界上提供蛋白品种最多的公司之一，领先的生产工艺和规模使其可以提供毫克到克级蛋白，价格优于同类公司。绝大部分产品是天然成熟型蛋白，而不含有标签蛋白。考虑到大部分研究者希望能更灵活地配制蛋白溶液，ProSpec-Tany绝大部分产品没有添加保护剂或盐，这就对工艺提出了更高的要求。同时，ProSpec-Tany绝大部分产品为冻干粉，因此易于运输和保存。
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