Synonym: Quercetin-3-rutinoside hydrate, Vitamin P hydrate

CAS Number:207671-50-9

Empirical Formula (Hill Notation): C₂₇H₃₀O₁₆ · xH₂O

Molecular Weight: 610.52 (anhydrous basis)

Beilstein Registry Number: 75455

EC Number: 205-814-1

MDL number:MFCD00149490

PubChem Substance ID:24899379

Description

Biochem/physiol Actions

A polyphenolic flavonoid that acts as an antioxidant and NO scavenger. It can attenuate peroxide production in glial cells by acting as a free radical scavenger and protect renal cells from oxidative injury. Inclusion of rutin in the diet of rats significantly reduced the appearance of single-strand breaks in nuclear DNA caused by hepatocarcinogens aflatoxin B₁ and N-nitrosodimethylamine. This protection from DNA damage was found to be due to a reduction in the induction of repair enzymes polymerase, DNA polymerase β and DNA ligase. Since DNA damage and inefficient repair are thought to initiate the process of carcinogenesis, effects of rutin on these functions suggests a protective role of this flavonoid against carcinogenesis induced by chemical carcinogens.

Properties

Assay≥94% (HPLC)

Formpowder

Coloryellow to green

Mp195 °C (dec.)(lit.)

solubility

pyridine: soluble50 mg/mL

DMSO: soluble

aqueous base: soluble

Safety

Personal Protective Equipmentdust mask type N95 (US), Eyeshields, Gloves

Hazard CodesXn

Risk Statements22

WGK Germany3