p53 / TP53抗体产品信息免疫原 : Recombinant Cynomolgus p53 / TP53 protein (Catalog#90001-CNAE)

Antibody Type : Rabbit Monoclonal Antibody ( Rabbit mAb Service Platform ) 
克隆号 : 014

抗体宿主 : Rabbit IgG
缓冲液 : 0.2 μm filtered solution in PBS, 5% trehalose may be added in some batches. Please read the hardcopy of COA or contact our customer service to confirm the formulation. 
制备方法 : This antibody was obtained from a rabbit immunized with purified, recombinant Cynomolgus p53 / TP53 (Catalog#90001-CNAE; E3U906; Met1-Asp393).
p53 / TP53抗体 Background
Cellular tumor antigen p53, also known as Antigen NY-CO-13, Phosphoprotein p53, Tumor suppressor p53, TP53 and p53, is an important inmulticellular organisms, where it regulates thecell cycleand functions as atumor suppressorthat is involved in preventingcancer. Tumor suppressor p53 (TP53 and p53) has many mechanisms of anticancer function, and plays a role in apoptosis, genomic stability, and inhibition ofangiogenesis. In its anti-cancer role, it works through several mechanisms. Tumor suppressor p53 (TP53 and p53) becomes activated in response to a myriad of stress types, which include but are not limited toDNA damage,oxidative stress, osmotic shock, ribonucleotide depletion, and deregulated oncogene expression. Tumor suppressor p53 (TP53 and p53) regulates the cell cycle. It functions as a tumor suppressor that is involved in preventing cancer. Tumor suppressor p53 (TP53 and p53) acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. It is involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. Tumor suppressor p53 (TP53 and p53) isoforms are expressed in a wide range of normal tissues but in a tissue-dependent manner. Isoform 2 is expressed in most normal tissues but is not detected in brain, lung, prostate, muscle, fetal brain, spinal cord and fetal liver. Isoform 3 is expressed in most normal tissues but is not detected in lung, spleen, testis, fetal brain, spinal cord and fetal liver. Isoform 7 is expressed in most normal tissues but is not detected in prostate, uterus, skeletal muscle and breast. Isoform 8 is detected only in colon, bone marrow, testis, fetal brain and intestine. Isoform 9 is expressed in most normal tissues but is not detected in brain, heart, lung, fetal liver, salivary gland, breast or intestine.
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