关键词：PCBP1抗体;多聚 ;多聚 ;Poly(rC)-binding protein 1; Alpha-CP1; Heterogeneous nuclear ribonucleoprotein E1; Nucleic acid-binding protein SUB2.3; hnRNP E1

中文名称：多聚 (rC)结合蛋白1多克隆抗体/PCBP1 Polyclonal Antibody

英文名称：PCBP1 Polyclonal Antibody

产品说明书：http://www.abbkine.cn/datasheet/ABP59842.pdf

产品描述：兔抗-多聚 (rC)结合蛋白1 多克隆抗体

This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. PCBP1 and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability.

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