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产品名称：PMA

产品别名：佛波醇12-十四酸酯13-乙酸酯(佛波酯)；12-十四酸酯13-乙酸佛波醇酯；Phorbol-12-Myristate-13-Acetate

CAS号：16561-29-8

英文别名：Phorbol-12-Myristate-13-Acetate; 12-O-Tetradecanoylphorbol 13-acetate, 4β,9α,12β,13α,20-Pentahydroxytiglia-1,6-dien-3-one 12-tetradecanoate

分子量：616.83

分子式：C₃₆H₅₆O₈

纯度：≥98%

外观：白色粉末

保存方法：Store at -20° C

描述：

PMA (Phorbol-12-Myristate-13-Acetate) is a diester of phorbol and is a tumor promoting compound extracted from croton oil. It is a reversible, highly potent protein kinase C (PKC) activator in vitro and in vivo at nM concentrations. PMA’s effects on PKC are attributed to its similarity to diacylgylerol, a natural activator of PKC. PMA activates Ca²⁺-ATPase and potentiates forskolin-induced cAMP formation. It has been shown to inhibit apoptosis induced by the Fas antigen, but PMA induces apoptosis in HL-60 promyelocytic leukemia cells.

应用：A reversible and highly potent protein kinase C (PKC) activator

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