【Molecular Wt.】87kDa

【Description】STAT1 is a member of the Signal Transducers and Activators of Transcription family of transcription factors. STAT1 is involved in upregulating genes due to a signal by either type I, type II, or type III interferons. In response to IFN-γ stimulation, STAT1 forms homodimers or heterodimers with STAT3 that bind to the GAS (Interferon-Gamma-Activated Sequence) promoter element; in response to either IFN-α or IFN-β stimulation, STAT1 forms a heterodimer with STAT2 that can bind the ISRE (Interferon-Stimulated Response Element) promoter element. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated.

【Species Reactivity】Human;mouse

【Tested applications】WB;ICC

【Antibody type】Mouse monoclonal Antibody

【Immunogen】recombinant protein

【Positive control】Jurkat, MCF-7

【Conjugate】Non-conjugated

【Alternative names】Signal transducer and activator of transcription 1 91kD antibody
CANDF7 antibody
DKFZp686B04100 antibody
IMD31A antibody
IMD31B antibody
IMD31C antibody
ISGF 3 antibody
ISGF-3 antibody
OTTHUMP00000163552 antibody
OTTHUMP00000165046 antibody
OTTHUMP00000165047 antibody
OTTHUMP00000205845 antibody
Signal transducer and activator of transcription 1 91kDa antibody
Signal transducer and activator of transcription 1 antibody
Signal transducer and activator of transcription 1, 91kD antibody
Signal transducer and activator of transcription 1-alpha/beta antibody
STAT 1 antibody
Stat1 antibody
STAT1_HUMAN antibody
STAT91 antibody
Transcription factor ISGF 3 components p91 p84 antibody
Transcription factor ISGF-3 components p91/p84 antibody

【Form】Liquid

【Stroage】Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.

【Stroage Buffer】1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

【Isotype】IgG2b

【Purity】Protein A purified.

【Subcellular location】Cytoplasm, nucleus

【Background References】1. "Fibroblast growth factor receptor-induced phosphorylation of STAT1 at the Golgi apparatus without translocation to the nucleus." Citores L., Bai L., Sorensen V., Olsnes S. J. Cell. Physiol. 212:148-156(2007)
2. "Analysis of STAT1 activation by six FGFR3 mutants associated with skeletal dysplasia undermines dominant role of STAT1 in FGFR3 signaling in cartilage." Krejci P., Salazar L., Kashiwada T.A., Chlebova K., Salasova A., Thompson L.M., Bryja V., Kozubik A., Wilcox W.R. PLoS ONE 3:E3961-E3961(2008)
3. "A novel form of human STAT1 deficiency impairing early but not late responses to interferons." Kong X.F., Ciancanelli M., Al-Hajjar S., Alsina L., Zumwalt T., Bustamante J., Feinberg J., Audry M., Prando C., Bryant V., Kreins A., Bogunovic D., Halwani R., Zhang X.X., Abel L., Chaussabel D., Al-Muhsen S., Casanova J.L., Boisson-Dupuis S. Blood 116:5895-5906(2010)

【DatasheetURL】http://www.huabio.com/upload/M1407-1.pdf

【Uniprot ID】P42224

【Raised in】Mouse

【Clone No.】G3-B11