分子量：
85-95kDa (monomer); 190kDa (dimer)
细胞定位：
Antigen Cellular Localization:Cell membrane; Single-pass type II membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV
形式：
0.5 ml at 200ug/ml with BSA and azide
参考文献：
1. Ben-David, D. et al. 2010. J Tissue Eng Regen Med. 4: 30-37. 2. Srouji, S. et al. 2009. Calcif. Tissue Int. 84: 138-145. 3. Kim, DS. et al. 2007. J. Dermatol. Sci. 46: 65-68.4. Fritzius, T. et al. 2006. Biochem J. 399(1): 9-20. 5. Harigae, H. et al. 2006. Int. J. Hematol. 84: 38-42.
产品概述：
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.This product is a high quality CD71 / Transferrin Receptor (TFRC) antibody - With BSA and Azide.
功能：
Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.
总结：
It recognizes a ~90-95kDa protein which is identified as cell surface transferrin receptor (CD71), a disulfide-bonded homodimeric glycoprotein of 180-190kDa (Workshop IV). This MAb is highly specific to CD71 and shows no cross-reaction with other related proteins. Ligand for transferrin receptor is the serum iron transport protein, transferrin. This receptor is broadly distributed in carcinomas, sarcomas, leukemias, and lymphomas. CD71/Transferrin receptor has been reported to be associated with cell proliferation in both normal and neoplastic tissues and useful in predicting clinical behavior or response to therapy in a number of malignancies including breast cancer.
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