ω-Conotoxin MVIID

SNX-238
A Blocker of N- and P-Type Ca_V Channels 
Cat #: STC-751
Sizes: 50 µg, 0.1 mg, 0.5 mg, 1 mg
Source: Synthetic peptide
MW: 2695 Da.
Net Peptide Content: 100%
Target: N-, P-type Ca²⁺ channels
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ω-conotoxins are small, disulfide-rich peptides from the venoms of predatory cone snails that inhibit neuronal voltage-gated Ca²⁺ channels involved in neurotransmitter release. ω-conotoxin-MVIID (ω-CTx-MVIID) was identified by sequence homology from Conus magus (Magician’s cone snail) cDNA library^1,4. ω-CTx-MVIID blocks Ca²⁺ current activated in whole-cell patch-clamp recordings from central neurons of goldfish². ω-conotoxin MVIID exhibits greater discrimination against the N-channel subtype than any other ω-conotoxin variant to date. ω-conotoxin MVIID has effects on “P-like” subtypes of Ca²⁺ channels. Furthermore, ω-CTx-MVIID inhibits synaptosomal voltage-sensitive Ca²⁺ uptake³.

Alomone labs is pleased to offer ω-Conotoxin MVIID (#STC-751), a highly purified synthetic peptide.

References

1. Haack, J.A. et al. (1993) Neuropharmacology32, 1151.
2. Tabata, T. et al. (1995) Neuropharmacology35, 633.
3. Gandia, L. et al. (1997) Pflugers Arch 435, 55.
4. Monje, V.D. et al. (1993) Neuropharmacology32, 1141.

• Our Bioassay
• Specifications
• Related Products

Our bioassay

Alomone Labs ω-Conotoxin MVIID blocks Ca_V2.2 channels heterologously expressed in Xenopus oocytes.
A. Time course of ω-Conotoxin MVIID (#STC-751) action on Ca_V2.2 maximum currents. Membrane potential was held at -100 mV and cells were stimulated by a 100 ms voltage ramp to +40 mV in the presence of 2 mM Ba²⁺. 0.2 µM (green) and 1 µM (red) ω-Conotoxin MVIID were perfused as indicated by the bar, each for 200s. B. Superimposed example traces of Ca_V2.2 channel current in the absence (control) and presence of 0.2 µM (red) and 1 µM (green) ω-Conotoxin MVIID (taken from the experiment in A).
OriginConus magus (Magus cone, Magician’s cone snail).
Purity>98%.
Effective concentration200 nM - 1 µM.
SequenceCQGRGASCRKTMYNCCSGSCNRGRC.
ModificationsDisulfide bonds between Cys¹-Cys¹⁶, Cys⁸-Cys²⁰, and Cys¹⁵-Cys²⁵. Cys²⁵ - C-terminal amidation.
Molecular formulaC₉₉H₁₆₄N₄₂O₃₃S₇.
Accession numberQ26350
Activityω-Conotoxin MVIID is a voltage-gated N-type Ca²⁺ channel blocker¹.
Storage before reconstitutionLyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
ReconstitutionAny other aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
Storage after reconstitutionUp to two weeks at 4°C or three months at -20°C.