产品英文名称：
Recombinant Human Galectin-8
英文简称:
LGALS 8
中文名称:
重组人半乳糖凝集素-8
背景资料:
Galectins are a family of animal lectins with an a大肠杆菌重组表达inity for beta-galactosides. This family has at least 14 identified members. Galectins share similarities in the CRD （the carbohydrate recognition domain）. Galectins are synthesized as cytosolic proteins. Though localized principally in the cytoplasm and lacking a classical signal peptide，galectins can also be stimulated to secretion by non-classical pathways or alternatively targeted to the nucleus. Galectins are involved in modulating cell-cell and cell-matrix interactions. Galectin-8 is a tandem-repeat-type member of the galectin family，consisting of 2 CRDs attached by a linker peptide. Galectin-8 is greatly expressed in lung carcinomas，a number of forms of prostate carcinomas，in addition to other tumor cells. Galectin-8 attaches to a subset of cell surface integrins to modulate ECM-integrin interactions. Once immobilized，Galectin-8 promotes cell adhesion by ligation and clustering of cell surface integrin receptors. On the other hand，as a soluble ligand，Galectin-8 can inhibit cell adhesion.
产品描述:
Galectin-8 Human Recombinant produced in E.Coli is a single，non-glycosylated，Polypeptide chain containing 317 amino acids and having a molecular mass of 35.8kDa.The LGALS8 is purified by proprietary chromatographic techniques.
来源宿主:
大肠杆菌重组表达
序列:
The sequence of the first five N-terminal amino acids was determined and was found to be Met-Met-Leu-Ser-Leu.
溶解建议:
提供的重组人半乳糖凝集素-8产品形式为冻干粉末.我们建议加无菌的18MΩ-cm水以配制工作储存液到不低于100ug/ml，后继实验过程中可根据实验要求进一步稀释.
保存建议：
人半乳糖凝集素-8产品在室温条件下可以保存3周，应该置于-18℃或更低温度下干燥保存.重新溶解后可置于4度保存2-7天，置于-18℃或更低温度下可保存更长时间.请避免反复冻融.
其他简介：
ProSpec是一家全球著名细胞因子蛋白及相关抗体生产和研发品牌。ProSpec的生产和研发工厂位于以色列，专注于蛋白（重组及合成）生产研发，其独有的细菌和哺乳动物表达和蛋白折叠技术使其能在17年内成长为国际一流的科研级蛋白供应商。目前ProSpec可以提供细胞因子，生长因子，激素，信号蛋白，病毒抗原等近800种重组蛋白和100多种抗体，是世界上提供蛋白品种最多的公司之一，领先的生产工艺和规模使其可以提供毫克到克级蛋白，价格优于同类公司。绝大部分产品是天然成熟型蛋白，而不含有标签蛋白。考虑到大部分研究者希望能更灵活地配制蛋白溶液，ProSpec-Tany绝大部分产品没有添加保护剂或盐，这就对工艺提出了更高的要求。同时，ProSpec-Tany绝大部分产品为冻干粉，因此易于运输和保存。
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