ProSpec（蛋白质专家）是以色列一家具有超过16年历史的，专业从事细菌来源重组蛋白生产的先进生物技术公司。ProSpec生产多种细胞因子、生长因子、趋化因子、激素、酶、病毒抗原和许多其他重组蛋白。在研究团队和科学家们的努力下，ProSpec已经拥有超过1700种可用于癌症、细胞凋亡、发育、内分泌学、免疫学、神经科学、蛋白酶及干细胞研究用重组蛋白、多肽和抗体。10多年蛋白纯化方面的经验使ProSpec公司生产成本低、产量高、效率高，其蛋白产品不仅纯度高、生物活性高，价格也非常具有优势。同时ProSpec针对客户的需要提供自定义重组蛋白生产服务。 ProSpec向客户提供蛋白质产品、服务和技术授权。因为创新的产品、卓越的客户服务和对细节的注重，ProSpec在科学界建立了良好的信誉，具有广泛的客户群，包括世界各地的学术、政府研究机构，生物技术和制药企业以及医院和基准实验室。
Synonyms Serum albumin, ALB, PRO0883, PRO0903, PRO1341, DKFZp779N1935, GIG20,
GIG42, PRO1708, PRO2044, PRO2619, PRO2675, UNQ696, SA, HSA.
Introduction
Albumin is synthesized in the liver as preproalbumin which has an N-terminal
peptide that is removed before the nascent protein is released from the rough
endoplasmic reticulum. The product, proalbumin, is in turn cleaved in the Golgi
vesicles to produce the secreted albumin. Albumin is a soluble, monomeric protein
which comprises about one-half of the blood serum protein. Albumin functions
primarily as a carrier protein for steroids, fatty acids, and thyroid hormones and
plays a role in stabilizing extracellular fluid volume. Mutations in this gene on
chromosome 4 result in various anomalous proteins. Albumin is a globular
unglycosylated serum protein of molecular weight 65,000. The human albumin gene
is 16,961 nucleotides long from the putative 'cap' site to the first poly (A) addition
site. It is split into 15 exons which are symmetrically placed within the 3 domains
that are thought to have arisen by triplication of a single primordial domain.
HSA is widely used to stabilize blood volume generally from donors but the fear of
contamination such as HIV & Hepatitis has enticed great interest in the recombinant
form which is identical to the natural blood.
Description
Human Serum Albumin contains 584 amino acid residues derived from the
prototypical human serum albumin sequence. Suitable for use in biochemical,
excipient (an inert substance used as a diluent or vehicle for a drug), culture media
and chromatographic applications.
Source Human Serum.
Physical
Appearance Sterile Filtered clear orange solution.
Formulation 0.25gr/ml solution containing no additives.
Stability Human Serum Albumin although stable at room temperature for 2 weeks should be
stored at 4°C.
Purity Greater than 99.0% as determined by(a) Analysis by RP-HPLC.
(b) Analysis by SDS-PAGE.
Applications
Formulation of Protein Therapeutics
Cell Storage: Cryopreservation
Vaccine formulation and manufacturing
Development of mammalian cell cultures
Infertility treatments
Coating for medical devices
Drug delivery
In vivo diagnostics.
Usage
Prospec's products are furnished for LABORATORY RESEARCH USE ONLY.
The product may not be used as drugs, agricultural or pesticidal products, food
additives or household chemicals.
Related
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» BSA
» HSA Recombinant
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