LRRTM3富含亮氨酸重复跨膜神经元蛋白3抗体

¥1380 - 2200
LMAI Bio
进口/国产
2022-03-24 09:54

上海联迈生物工程有限公司

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上海联迈生物工程有限公司
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产品属性
供应商上海联迈生物工程有限公司
数量大量
目录编号LM-11571R
克隆性多克隆
抗原来源Rabbit
保质期1年
抗体英文名LRRTM3
抗体名富含亮氨酸重复跨膜神经元蛋白3抗体
宿主Rabbit
适应物种Human, Mouse, Rat, Chicken, Pig, Cow, Rabbit, Sheep, Monkey,
免疫原KLH conjugated synthetic peptide derived from human LRRTM3 (31-120aa):31-120/581 <Extracellular>
亚型IgG
形态Lyophilized or Liquid
应用范围WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 Flow-Cyt=1μg/Test ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
浓度1mg/ml
保存条件Store at -20 °C
规格100ul  200ul
产品说明
LRRTM3富含亮氨酸重复跨膜神经元蛋白3抗体
英文名称LRRTM3
中文名称富含亮氨酸重复跨膜神经元蛋白3抗体
别 名Leucine rich repeat transmembrane neuronal protein 3; Leucine-rich repeat transmembrane neuronal protein 3; LRRT3_HUMAN; Lrrtm3; MGC131810; PRO1693; UNQ803.
规格价格100ul/1380元 购买 200ul/2200元 购买 大包装/询价
说 明 书100ul 200ul
研究领域细胞生物 神经生物学 信号转导 细胞膜受体
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Chicken, Pig, Cow, Rabbit, Sheep, Monkey, 
产品应用WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 Flow-Cyt=1μg/Test ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复) 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量63kDa
细胞定位细胞膜 
性 状Lyophilized or Liquid
浓 度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human LRRTM3 (31-120aa):31-120/581 <Extracellular>
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMedPubMed
产品介绍background:
The leucine-rich (LRR) repeat is a 20-30 amino acid motif that forms a hydrophobic Alpha/Beta horseshoe fold, allowing it to accommodate several leucine residues within a tightly packed core. All LRR repeats contain a variable segment and a highly conserved segment, the latter of which accounts for 11 or 12 residues of the entire LRR motif. The LRRTM protein family plays a role in the regulation of various cellular events during nervous system development. Localizing predominantly to the nervous system, LRRTM family members are known to exhibit synaptogenic activity. LRRTM3 (leucine rich repeat transmembrane neuronal 3) is a 581 amino acid single-pass type I membrane protein belonging to the LRRTM family. LRRTM3 is involved in the development and maintenance of the vertebrate nervous system, and contains ten LRR repeats. Expressed in neuronal tissues, LRRTM3 is encoded by a gene that maps to a region of chromosome 10 that has been linked to late-onset Alzheimer disease and elevated plasma Beta-Amyloid. As a result of alternative splicing events, two LRRTM3 isoforms exist.

Function:
May play a role in the development and maintenance of the vertebrate nervous system.

Subcellular Location:
Cell membrane; Single-pass type I membrane protein (By similarity). Cell junction, synapse, postsynaptic cell membrane; Single-pass type I membrane protein

Tissue Specificity:
Expressed in neuronal tissues.

Similarity:
Belongs to the LRRTM family.
Contains 10 LRR (leucine-rich) repeats.
Contains 1 LRRCT domain.
Contains 1 LRRNT domain.

SWISS:
Q86VH5

Gene ID:
347731

Database links:
Entrez Gene: 347731 Human
Entrez Gene: 216028 Mouse
Entrez Gene: 294380 Rat
Omim: 610869 Human
SwissProt: Q86VH5 Human
SwissProt: Q8BZ81 Mouse
Unigene: 652155 Human
Unigene: 431318 Mouse
Unigene: 214114 Rat


Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

产品图片
Blank control (blue line): Mouse brain (fixed with 2% paraformaldehyde for 10 min at room temperature, and then stained with Primary Antibody for 30 min at room temperature). 
Primary Antibody (green line): Rabbit Anti-LRRTM3 antibody (bs-11571R),Dilution: 1μg /10^6 cells; 
Isotype Control Antibody (orange line): Rabbit IgG .
Secondary Antibody (white blue line): Goat anti-rabbit IgG-FITC,Dilution: 1μg /test.