可溶性凝集素样氧化低密度脂蛋白受体1抗体0.2ml/200μg

¥1000 - 3500
上海谷研
进口/国产
2022-03-24 11:46

上海谷研实业有限公司

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上海谷研实业有限公司
刘小姐
18321818584 021-39921927
3004901493@qq.com
产品属性
抗体名可溶性凝集素样氧化低密度脂蛋白受体1抗体
抗体英文名Anti-sLOX 1
靶点详见说明书
浓度1mg/1ml
应用范围WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 ICC=1:100-500 IF=1:100-500
宿主详见说明书
供应商上海谷研
数量54
级别详见说明书
目录编号详见说明书
抗原来源Rabbit
保质期详见说明书
适应物种详见说明书
标记物详见说明书
克隆性多克隆
保存条件Store at -20 °C
形态详见说明书
亚型IgG
免疫原KLH conjugated synthetic peptide derived from human sLOX 1
规格0.2ml/200μg
产品说明
可溶性凝集素样氧化低密度脂蛋白受体1抗体0.2ml/200μg详细说明如下:
英文名称 Anti-sLOX 1

中文名称可溶性凝集素样氧化低密度脂蛋白受体1抗体0.2ml/200μg
Soluble Lectin-like oxidized low density lipoprotein receptor-1; sLOX-1; soluble form; C-type lectin domain family 8 member A; CLEC8A; hLOX 1; hLOX-1; Lectin like oxidized LDL receptor 1; Lectin like oxLDL receptor 1; Lectin type oxidized LDL receptor 1; Lectin-like oxidized LDL receptor 1; Lectin-like oxLDL receptor 1; Lectin-type oxidized LDL receptor 1; LOX-1; Olr1; OLR1_HUMAN; Ox LDL receptor 1; Ox-LDL receptor 1; Oxidised low density lipoprotein (lectin like) receptor 1; Oxidized low density lipoprotein receptor 1; Oxidized low density lipoprotein receptor 1 soluble form ; Oxidized low-density lipoprotein receptor 1; SCARE1; Scavenger receptor class E, member 1.

1mg/1ml
0.2ml/200μg
抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Human, Mouse, Rat, Pig, Cow, Horse, Rabbit
产品类型一抗
研究领域心血管免疫学合成与降解
蛋白分子量 predicted molecular weight:31kDa
Lyophilized or Liquid
KLH conjugated synthetic peptide derived from human sLOX 1
IgG
纯化方法 affinity purified by Protein A
0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

可溶性凝集素样氧化低密度脂蛋白受体1抗体0.2ml/200μg产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1:100-500 ICC=1:100-500 IF=1:100-500
(石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria.
Function :
Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria.
Subcellular Location :
Cell membrane; Single-pass type II membrane protein. Secreted. Note=A secreted form also exists.
Tissue Specificity :
Expressed at high level in endothelial cells and vascular-rich organs such as placenta, lung, liver and brain, aortic intima, bone marrow, spinal cord and substantia nigra. Also expressed at the surface of dendritic cells. Widely expressed at intermediate and low level.

可溶性凝集素样氧化低密度脂蛋白受体1抗体0.2ml/200μg抗体的多样性:
抗体的异质性。抗体的组成极为复杂,是由成千上万、多种多样的免疫球蛋白(Ig)分子所组成。这些Ig分子在形状、大小、结构以及氨基酸的组成和排列上,既相似,又有差别。由于有差别,它们的电泳活性就有很大的变化。
因为抗体具有与抗原决定簇相对应的结合部位(抗原结合簇),所以抗体与抗原的结合具有特异性。另一方面,抗体本身是一种蛋白质,具有本身的氨基酸组成、排列和立体结构,对异种动物来说,它又是抗原。各类Ig都具有可用血清学方法检出的抗原特异性,它们表现出不同的血清学类型。
可溶性凝集素样氧化低密度脂蛋白受体1抗体0.2ml/200μg抗体的生活习性:
(1)结合特异性抗原:抗体与其他免疫球蛋白分子区别,就在于抗体能与相应抗原发生特异性结合,在体内导致生理或病理效应;在体外产生各种直接或间接的可见的抗原抗体结合反应。抗体是靠其分子上的特殊的结合部位与抗原结合的。
(2)激活补体:抗体与相应抗原结合后,借助暴露的补体结合点去激活补体系统、激发补体的溶菌、溶细胞等免疫作用。
(3)结合细胞:不同类别的免疫球蛋白,可结合不同种的细胞,产生不同的疚,参与免疫应答。
(4)可通过胎盘及粘膜:免疫球蛋白G(IgG)能通过胎盘进入胎儿血流中,使胎儿形成自然被动免疫。免疫球蛋白A(IgA)可通过消化道及呼吸道粘膜,是粘膜局部抗感染免疫的主要因素。
(5)具有抗原性:抗体分子是一种蛋白质,也具有刺激机体产生免疫应答的性能。不同的免疫球蛋白分子,各具有不同的抗原性。
(6)抗体对理化因子的抵抗力与一般球蛋白相同:不耐热,60~70℃即被破坏。各种酶及能使蛋白质凝固变性的物质,均能破坏抗体的作用。抗体可被中性盐类沉淀。在生产上常可用硫酸铵或硫酸钠从免疫血清中沉淀出含有抗体的球蛋白,再经透析法将其纯化。
公司,由具有资深行业背景和丰富市场经验的专业人士组成,致力于为生命科学研究领域提供优质产品,为广大科研工作者提供最优质服务。既能满足研发类客户对产品种类、包装、纯度的特殊要求,也能满足生产型企业从小试、中试到规模化生产各个阶段的综合需求。
可溶性凝集素样氧化低密度脂蛋白受体1抗体0.2ml/200μg一抗和二坑的区别:
第一抗体就是平常所说的抗体,即能和抗原特异性结合。
第二抗体是能和抗体结合的,即抗体的抗体。主要用于检测抗体的存在。
一抗是针对抗原的抗体,二抗是针对一抗的抗体。即抗体也可以充当抗原刺激机体产生抗体。也就是说,抗原进入机体刺激机体免疫系统产生免疫应答,由B细胞可以产生与相应抗原发生特异性结合的特殊蛋白质。
一抗二抗都是一种可以特异结合别的物质的基团,而且一抗可以至少结合两种其他基团(底物和二抗)。
一抗:可以特异结合底物,就是识别出我们想要检测的东西。一抗和底物结合与否用肉眼是看不出来的。
二抗:可以和一抗结合,并带有可以被检测出的标记(如带荧光、放射性、化学发光或显色基团),作用是检测一抗。 如果一抗自己带有可以被检测出的标记(如带荧光、放射性、化学发光或显色基团),则不需要二抗。但这样成本很高,因为一种一抗只识别一种底物。所以如今的设计一般是二抗带上可检测标记,再来检测一抗。而一抗识别底物。这样,当一抗结合到底物上,就可以通过二抗检测出来。 


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可溶性凝集素样氧化低密度脂蛋白受体1抗体0.2ml/200μg人钾电压阀门通道亚家族B成员2(KCNB2)ELISA试剂盒 现货供应 0.312-20 ng/mL

人假定的RNA结合蛋白3(RBM3)ELISA试剂盒 现货供应 78-5000 pg/mL
人间α-胰蛋白酶抑制因子重链H1(ITI-HC1)ELISA试剂盒 现货供应 0.78-50 ng/mL
人间α-胰蛋白酶抑制因子重链H5(ITIH5L)ELISA试剂盒 现货供应 0.156-10 ng/mL
人间白素结合因子(ILF3)ELISA试剂盒 现货供应 15.6-1000 pg/mL
人间隙连接α-1蛋白(GJA1)ELISA试剂盒 现货供应 0.156-10 ng/mL
人碱性成纤维细胞生长因子(bFGF)ELISA试剂盒 现货供应 0.78-50 ng/mL
人腱生蛋白N(TN-N)ELISA试剂盒 现货供应 0.312-20 ng/mL
人降钙素(CT)ELISA试剂盒 现货供应 7.8-500 pg/mL
人降钙素基因相关肽1(CGRP-1)ELISA试剂盒 现货供应 0.078-5 EU/mL