产品背景: Immunoglobulin G2 (IgG2) is a member of many immunoglobulin G developed and secreted by effective B cells. In wake of cutting by pepsin, IgG is divided into two F(ab)s with one antigen binding site and a high conserved Fc segment. The Fc segment bears a highly conserved N-glycosylation site. There are two members of IgG2: IgG2a and IgG2b. It was found that IgG2a was superior to IgG1 in activating complement. The glycosylation of the circulating immunoglobulin-γ (IgG) antibody molecules changes in rheumatoid arthritis.
产品描述: Mouse IgG2a Fc, Tag Free contains no "tag", and has a calculated MW of 26.4 kDa. The predicted N-terminus is Glu 98. As a result of glycosylation, the reducing (R) protein migrates as 25-30 kDa, and the non-reducing (NR) protein migrates as 50-60 kDa in SDS-PAGE.
