本公司提供科研Phospho-Dab1 (Tyr198)磷酸化磷脂蛋白受体Dab1抗体，抗体质量可靠，订购Phospho-Dab1 (Tyr198)磷酸化磷脂蛋白受体Dab1抗体请联系在线客服或者销售人员。
抗体参数如下>>>>
中文名称：磷酸化磷脂蛋白受体Dab1抗体
英文名称：Anti-Phospho-Dab1 (Tyr198)
货号：bs-11548R
抗体来源：兔
克隆类型：多克隆
蛋白分子量：predicted molecular weight: 80kDa
纯化方法：affinity purified by Protein A
交叉反应：hu, mo, rat
测试应用：ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
产品背景介绍：Dab1, a homolog of the Drosophila Disabled protein, is an adaptor protein involved in neural development. This cytoplasmic protein is tyrosine-phosphorylated during rapid expansion of the developing nervous system, and it is thought to interact with other proteins via a domain similar to the PTB domains of the Shc family. Dab1 has been shown to interact with the SH2 domains of Src, Fyn and Abl (1). Mutations in Dab1 result in widespread abnormalities in the brain, similar to those seen in Reelin mutants (2). Reelin is a secreted protein thought to play a role in directing migrating neurons (3). Evidence suggests that Dab1 functions downstream of Reelin in a signaling pathway involved in positioning cells in the developing brain (4). Dab2 (also designated DOC-2) is a mitogen-responsive phosphoprotein that binds the SH3 domain of Grb2, and it is thought to be a negative regulator of growth (5).Function : Adapter molecule functioning in neural development. May regulate SIAH1 activity.Post-translational modifications : Phosphorylated on Tyr-198 and Tyr-220 upon reelin induction in embryonic neurons (By similarity). Also phosphorylated on Ser-524 independently of reelin signaling.Similarity : Contains 1 PID domain.