产品英文名称：
Recombinant Human Beta 2 Glycoprotein-I

英文简称:
B2GP1

中文名称:
重组人β2糖蛋白I

背景资料:
?2 Glycoprotein I （?2 GP I） is a serum protein with a single polypeptide chain consisting of 326 amino acids and having a molecular weight of 50 kDa. The protein is also known by the alternative name Apolipoprotein H （ApoH） which gives an indication of its phospholipid binding function.Since the detection of ?2 Glycoprotein I as a target of antiphospholipid antibodies in 1990 the discussion about the clinical relevance of ?2 GP I is still controversial. It is well established that anticardiolipin antibodies are a very heterogeneous group and that ?2 GP I is only one of several potential targets for anticardiolipin antibodies. Nevertheless it is generally accepted that the binding of ?2 GP I to anionic lipids or surface is essential for the di昆虫Sf9细胞中重组表达erential detection of anticardiolipin antibodies associated with autoimmune diseases （versus those associated with infectious diseases like syphilis， tuberculosis， AIDS， etc）.The close relationship of ?2 GP I antibodies and cardiolipin antibodies may indicate that the ?2 GP I isotypes have the same clinical relevance as the cardiolipin isotypes， where IgM， IgG and IgA autoantibodies have bb2 Glycoprotein-I Human Recombinant produced in SF9 is a glycosylated， polypeptide chain containing 326 amino acids and having a molecular mass of 38，200 Dalton （excluding glycosylation）， 45 kDa total mass.B2GP1 is expressed with a -6xHis tag and purified by proprietary chromatographic techniques.n observed and are routinely determined diagnostic targets.B2GP1 antibodies and anticardiolipin antibodies can be detected in patients with arterial and venous thrombosis， recurrent fetal loss， thrombosis and SLE. The titers of anticardiolipin and anti-?2 GP I antibodies usually fluctuate su昆虫Sf9细胞中重组表达iciently that they cannot be used for disease monitoring.

产品描述:
b2 Glycoprotein-I Human Recombinant produced in SF9 is a glycosylated， polypeptide chain containing 326 amino acids and having a molecular mass of 38，200 Dalton （excluding glycosylation）， 45 kDa total mass.B2GP1 is expressed with a -6xHis tag and purified by proprietary chromatographic techniques.
来源宿主:
昆虫Sf9细胞中重组表达

序列:


溶解建议:
Sterile Filtered clear solution. B2GP1 is supplied in 16mM HEPES buffer pH-7.2， 200mM NaCl， and 20% glycerol.

保存建议：
Store at 4℃ if entire vial will be used within 2-4 weeks.Store， frozen at -20℃ for longer periods of time.Avoid multiple freeze-thaw cycles.
其他简介：

ProSpec是一家全球著名细胞因子蛋白及相关抗体生产和研发品牌。ProSpec的生产和研发工厂位于以色列，专注于蛋白（重组及合成）生产研发，其独有的细菌和哺乳动物表达和蛋白折叠技术使其能在17年内成长为国际的科研级蛋白供应商。目前ProSpec可以提供细胞因子，生长因子，激素，信号蛋白，病毒抗原等近800种重组蛋白和100多种抗体，是世界上提供蛋白品种最多的公司之一，领先的生产工艺和规模使其可以提供毫克到克级蛋白，价格优于同类公司。绝大部分产品是天然成熟型蛋白，而不含有标签蛋白。考虑到大部分研究者希望能更灵活地配制蛋白溶液，ProSpec-Tany绝大部分产品没有添加保护剂或盐，这就对工艺提出了更高的要求。同时，ProSpec-Tany绝大部分产品为冻干粉，因此易于运输和保存。