产品货号:jlcR19629
英文名称:Selenoprotein M
中文名称:硒蛋白M抗体
别名:Selenoprotein-M; Selenoprotein SelM; SELM; SELM_HUMAN; SelM protein; SEPM.
研究领域:肿瘤心血管细胞生物免疫学发育生物学神经生物学信号转导
抗体来源:Rabbit
克隆类型:Polyclonal
交叉反应: Human,
产品应用:ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分子量:14kDa
细胞定位:细胞浆
性状:Lyophilized or Liquid
浓度:1mg/ml
免疫原:KLH conjugated synthetic peptide derived from human Selenoprotein M:24-100/145
亚型:IgG
纯化方法:affinity purified by Protein A
储存液:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件:Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed :PubMed
产品介绍: Selenoprotein M is widely expressed and expressed highly in the mammalian brain. It is localized to the perinuclear structures (Golgi/ER). A growing body of evidence relates selenium to cancer prevention, immune system function, male fertility, cardiovascular disorder, control of the aging and neurodiseases process. Selenoproteins are thought to be responsible for the majority of these biomedical effects of selenium. Approximately 17 selenoproteins have been identified until now. Although the function of many selenoproteins are unknown, some play important roles in antioxidant mechanisms. It has been also implicated in the regulation of signaling pathways through catalysis of thiol/disulfide exchange. The roles of Selenoprotein M have not been clearly identified until present time.
Function:
May function as a thiol-disulfide oxidoreductase that participates in disulfide bond formation.
Subcellular Location:
Cytoplasm; perinuclear region. Endoplasmic reticulum Probable. Golgi apparatus Probable. Note: Localized to perinuclear structures corresponding to Golgi and endoplasmic reticulum.
Similarity:
Belongs to the selenoprotein M/SEP15 family.
SWISS:
Q8WWX9
Gene ID:
140606
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
