Sciencell公司产品由上海中乔新舟生物科技有限公司优质供应

美国ScienCell研究实验室（www.sciencellonline.com）成立于1999年，公司总部位于美国加州的圣地亚哥。主要致力
于实验室科研用原代细胞、原代细胞专用培养基、原代细胞无血清培养基、干细胞、干细胞培养基、干细胞无血清培养
基的研究和开发，在全球拥有众多客户。在国内销售15年来，很多老师应用其产品发表了高质量的SCI文章，且有着极高
的文献引用率。凭借着严格的质控和优秀的产品品质，深受广大科研工作者的信赖。

ScienCell研究实验室生产的原代细胞、原代细胞专用培养基都经过了严格的质量控制，细胞纯度可达98％。其中包括21
种人体正常细胞系统，90多种不同细胞类型。大多数细胞在全球唯有ScienCell实验室能够成功分离，产品质量过硬。
确保了实验结果的重复性和连贯性。

请登录Sciencell公司官方网站（www.zqxzbio.com或www.sciencellonline.com）以确保购买正规公司产品

人表皮黑色素细胞--浅色素说明：
货号：2200



人黑色素细胞是神经嵴衍生细胞，位于人的某些器官，如皮肤、眼睛、内耳和软脑膜。黑色素细胞不能向这些器官的
移动，可以解释先天性皮肤白斑（斑驳病）跟虹膜异色（不同颜色并置）之间的关系以及Waardenburg综合征的先天
性耳聋。皮肤黑色素细胞合成并转运黑色素到周围的角质细胞，使皮肤有色素沉积以保护皮肤对抗阳光辐射。随着新
的细胞培养技术和改良的培养方法，在成功培养这类细胞在纯种群时，发现了新型的黑色素细胞基因——msgl, 它能
编码一种与色素沉着相关的核蛋白。 <2200>人表皮黑色素细胞(HEM-l),<2210>人表皮黑色素细胞(HEM-m),
<2220>人表皮黑色素细胞(HEM-d)提取于人表皮组织，原代冻存。每管含有细胞数>5×10⁵cells/ml，此细胞通过
Fibronectin和NGF-receptor(p75)免疫荧光染色验证，经测试不含有HIV-1、HBV、HCV、支原体、细菌、酵母和
真菌。细胞可以达到15倍增。

推荐培养基:(MelM, Cat. No. 2201)

DISCRIPTION

The melanocyte is a neural crest-derived cell that localizes in humans to several organs including the
epidermis, eye, inner ear and leptomeninges. The failure of melanocytes to migrate to these locations
explains the association of congenital white spotting of the skin (piebaldism) with heterochromia (the
juxtaposition of different colors) in the iris as well as congenital deafness in Waardenburg syndrome. In
the skin, melanocytes synthesize and transfer melanin pigments to surrounding keratinocytes, leading to
skin pigmentation and protection against solar exposure. Recent progress in basic cell-culture technology,
along with an improved understanding of culture requirements, has led to the success in culturing of this special
cell type in pure population [1, 2] and the discovery of a novel melanocyte-specific gene, msg1, which encodes
a nuclear protein and is associated with pigmentation [3].
HEM from ScienCell Research Laboratories are isolated from human epidermis. HEM are cryopreserved on passage
one culture and delivered frozen. Each vial contains >5 x 10⁵ cells in 1 ml volume. HEM are characterized by
immunofluorescent method with antibodies to fibronectin and NGF-receptor (p75). HEM are negative for HIV-1,
HBV, HCV, mycoplasma, bacteria, yeast and fungi. HEM are guaranteed to further expand for 15 population doublings
in the condition provided by ScienCell Research Laboratories.
Reference
[1]. Eisinger, M. and Marko, O. (1982) Selective proliferation of normal human melanocytes in vitro in the presence
of phorbol ester and cholera toxin. Proc. Natl. Acad. USA 79:2018-2022.
[2]. Tang, A., Eller, M. S., Hara, M., Yaar, M., Hirohashi, S. and Gilchrest, B. A. (1994) E-cadherin is the major mediator
of human melanocyte adhesion to keratinocytes in vitro. J. Cell Sci. 107:983-992.
[3]. Shioda, T., Fenner, M. H. and Isselbacher, K. J. (1996) msg1, a novel melanocyte-specific gene, encodes a nuclear
protein and is associated with pigmentation. Proc. Natl. Acad. Sci. USA 93:12298-12303.

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